DNA damage foci: Meaning and significance
The discovery of DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and
the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a …
the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a …
Persistent γH2AX: A promising molecular marker of DNA damage and aging
One of the earliest cellular responses to DNA double strand breaks (DSBs) is the
phosphorylation of the core histone protein H2AX (termed γH2AX). Persistent γH2AX is the …
phosphorylation of the core histone protein H2AX (termed γH2AX). Persistent γH2AX is the …
Prediction of mucositis risk secondary to cancer therapy: a systematic review of current evidence and call to action
Purpose Despite advances in personalizing the efficacy of cancer therapy, our ability to
identify patients at risk of severe treatment side effects and provide individualized supportive …
identify patients at risk of severe treatment side effects and provide individualized supportive …
Influence of nucleoshuttling of the ATM protein in the healthy tissues response to radiation therapy: toward a molecular classification of human radiosensitivity
Purpose Whereas post–radiation therapy overreactions (OR) represent a clinical and
societal issue, there is still no consensual radiobiological endpoint to predict clinical …
societal issue, there is still no consensual radiobiological endpoint to predict clinical …
Quantification of radiation-induced DNA double strand break repair foci to evaluate and predict biological responses to ionizing radiation
Radiation-induced foci (RIF) are nuclear puncta visualized by immunostaining of proteins
that regulate DNA double-strand break (DSB) repair after exposure to ionizing radiation. RIF …
that regulate DNA double-strand break (DSB) repair after exposure to ionizing radiation. RIF …
Post-translational modifications of H2A histone variants and their role in cancer
Histone variants are chromatin components that replace replication-coupled histones in a
fraction of nucleosomes and confer particular characteristics to chromatin. H2A variants …
fraction of nucleosomes and confer particular characteristics to chromatin. H2A variants …
Radiogenomics: A systems biology approach to understanding genetic risk factors for radiotherapy toxicity?
Adverse reactions in normal tissue after radiotherapy (RT) limit the dose that can be given to
tumour cells. Since 80% of individual variation in clinical response is estimated to be caused …
tumour cells. Since 80% of individual variation in clinical response is estimated to be caused …
H2A. X phosphorylation in oxidative stress and risk assessment in plasma medicine
CS Schütz, MB Stope… - Oxidative Medicine and …, 2021 - Wiley Online Library
At serine139‐phosphorylated gamma histone H2A. X (γH2A. X) has been established over
the decades as sensitive evidence of radiation‐induced DNA damage, especially DNA …
the decades as sensitive evidence of radiation‐induced DNA damage, especially DNA …
DNA damage response assessments in human tumor samples provide functional biomarkers of radiosensitivity
H Willers, L Gheorghiu, Q Liu, JA Efstathiou… - Seminars in radiation …, 2015 - Elsevier
Predictive biomarkers are urgently needed for individualization of radiation therapy and
treatment with radiosensitizing anticancer agents. Genomic profiling of human cancers …
treatment with radiosensitizing anticancer agents. Genomic profiling of human cancers …
Potential screening assays for individual radiation sensitivity and susceptibility and their current validation state
Abstract Purpose: The workshop on 'Individual Radiosensitivity and Radiosusceptibility'
organized by MELODI and CONCERT on Malta in 2018, evaluated the current state of …
organized by MELODI and CONCERT on Malta in 2018, evaluated the current state of …