Aneurysmal subarachnoid hemorrhage (SAH) can lead to devastating outcomes including
vasospasm, cognitive decline, and even death. Currently, treatment options are limited for …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Recent work on glial cell physiology has revealed that glial cells, and astrocytes in
particular, are much more actively involved in brain information processing than previously …

Estrogen is an important hormone signal that regulates multiple tissues and functions in the
body. This review focuses on the neurotrophic and neuroprotective actions of estrogen in the …

In this viewpoint article, I summarize data showing that the astrocytic swelling that occurs
early after the acute CNS pathologies ischemia and traumatic brain injury is damaging. We …

Within the last few years, there has been a growing interest in the neuroprotective effects of
estrogen and the possible beneficial effects of estrogen in neurodegenerative diseases such …

The volume-regulated anion channel (VRAC) is a ubiquitously expressed yet highly
enigmatic member of the superfamily of chloride/anion channels. It is activated by cellular …

Background: Tamoxifen (TX), a selective estrogen receptor modulator, enhances glutamate
transporter (GLT-1) expression in astrocytes. Results: TX up-regulated GLT-1 expression via …

Previous studies have indicated that volume regulated anion channels (VRACs) may be
involved in the pathology of the ischemic brain cortical penumbra due to activation of VRAC …

Tamoxifen has been found to be neuroprotective in both transient and permanent
experimental ischemic stroke. However, it remains unknown whether this agent shows a …