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Oral squamous cell carcinomas: state of the field and emerging directions
Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of the oral
cavity. It accounts for approximately 90% of oral malignancies and impairs appearance …
cavity. It accounts for approximately 90% of oral malignancies and impairs appearance …
miRNA: a promising therapeutic target in cancer
microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by
complementarity pairing. Since discovery, they have been reported to be involved in a …
complementarity pairing. Since discovery, they have been reported to be involved in a …
Metal–organic frameworks as photoluminescent biosensing platforms: mechanisms and applications
Biosensing is of vital importance for advancing public health through monitoring
abnormalities in biological systems, which may be potentially associated with certain body …
abnormalities in biological systems, which may be potentially associated with certain body …
Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours
Background In this first-in-human, Phase 1 study of a microRNA-based cancer therapy, the
recommended Phase 2 dose (RP2D) of MRX34, a liposomal mimic of microRNA-34a (miR …
recommended Phase 2 dose (RP2D) of MRX34, a liposomal mimic of microRNA-34a (miR …
Advances in multiplexed techniques for the detection and quantification of microRNAs
MicroRNA detection is currently a crucial analytical chemistry challenge: almost 2000
papers were referenced in PubMed in 2018 and 2019 for the keywords “miRNA detection …
papers were referenced in PubMed in 2018 and 2019 for the keywords “miRNA detection …
The role of non-coding RNAs in oncology
For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …
Enterotoxigenic Bacteroides fragilis promotes intestinal inflammation and malignancy by inhibiting exosome-packaged miR-149-3p
Background & Aims Enterotoxigenic Bacteroides fragilis (ETBF) is strongly associated with
the occurrence of inflammatory bowel disease (IBD), colitis-associated colorectal cancer …
the occurrence of inflammatory bowel disease (IBD), colitis-associated colorectal cancer …
HMDD v3. 0: a database for experimentally supported human microRNA–disease associations
Comprehensive databases of microRNA–disease associations are continuously demanded
in biomedical researches. The recently launched version 3.0 of Human MicroRNA Disease …
in biomedical researches. The recently launched version 3.0 of Human MicroRNA Disease …
Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors
Purpose Naturally occurring tumor suppressor microRNA-34a (miR-34a) downregulates the
expression of> 30 oncogenes across multiple oncogenic pathways, as well as genes …
expression of> 30 oncogenes across multiple oncogenic pathways, as well as genes …
MicroRNAs and complex diseases: from experimental results to computational models
Plenty of microRNAs (miRNAs) were discovered at a rapid pace in plants, green algae,
viruses and animals. As one of the most important components in the cell, miRNAs play a …
viruses and animals. As one of the most important components in the cell, miRNAs play a …