Non-apoptotic cell death-based cancer therapy: Molecular mechanism, pharmacological modulators, and nanomedicine
As an emerging cancer therapeutic target, non-apoptotic cell death such as ferroptosis,
necroptosis and pyroptosis, etc., has revealed significant potential in cancer treatment for …
necroptosis and pyroptosis, etc., has revealed significant potential in cancer treatment for …
[HTML][HTML] RNA nanotechnology-mediated cancer immunotherapy
RNA molecules (eg, siRNA, microRNA, and mRNA) have shown tremendous potential for
immunomodulation and cancer immunotherapy. They can activate both innate and adaptive …
immunomodulation and cancer immunotherapy. They can activate both innate and adaptive …
Smart transformable nanoparticles for enhanced tumor theranostics
The physical morphologies of nanoparticles, especially size and shape, always significantly
influence their biological behaviors. In the past, nanoparticles with constant physical …
influence their biological behaviors. In the past, nanoparticles with constant physical …
Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models
Increasing clinical evidence has demonstrated that the deletion or mutation of tumor
suppressor genes such as the gene-encoding phosphatase and tensin homolog deleted on …
suppressor genes such as the gene-encoding phosphatase and tensin homolog deleted on …
A size‐changeable collagenase‐modified nanoscavenger for increasing penetration and retention of nanomedicine in deep tumor tissue
F Xu, X Huang, Y Wang, S Zhou - Advanced Materials, 2020 - Wiley Online Library
The complex tumor microenvironment constitutes a variety of barriers to prevent
nanoparticles (NPs) delivery and results in extremely low accumulation of nanomedicines in …
nanoparticles (NPs) delivery and results in extremely low accumulation of nanomedicines in …
Polymeric nanoparticles promote macrophage reversal from M2 to M1 phenotypes in the tumor microenvironment
Immunotherapy has shown promising treatment effects for a variety of cancers. However, the
immune treatment efficiency for solid tumors is limited owing to insufficient infiltration of …
immune treatment efficiency for solid tumors is limited owing to insufficient infiltration of …
[HTML][HTML] Targeted regulation of autophagy using nanoparticles: New insight into cancer therapy
Normal cells depend on autophagy to maintain cellular homeostasis by recycling damaged
organelles and misfolded proteins and degrading toxic agents. Similar to apoptosis …
organelles and misfolded proteins and degrading toxic agents. Similar to apoptosis …
Toxic effects and involved molecular pathways of nanoparticles on cells and subcellular organelles
N Liu, M Tang - Journal of Applied Toxicology, 2020 - Wiley Online Library
Owing to the increasing application of engineered nanoparticles (NPs), besides the
workplace, human beings are also exposed to NPs from nanoproducts through the skin …
workplace, human beings are also exposed to NPs from nanoproducts through the skin …
Silica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction
M Wang, J Li, S Dong, X Cai, A Simaiti, X Yang… - Particle and Fibre …, 2020 - Springer
Background Wide applications of nanoparticles (NPs) have raised increasing concerns
about safety to humans. Oxidative stress and inflammation are extensively investigated as …
about safety to humans. Oxidative stress and inflammation are extensively investigated as …
Development of a pH-responsive polymersome inducing endoplasmic reticulum stress and autophagy blockade
F Xu, X Li, X Huang, J Pan, Y Wang, S Zhou - Science advances, 2020 - science.org
Autophagy is involved in the occurrence and development of tumors. Here, a pH-responsive
polymersome codelivering hydroxychloroquine (HCQ) and tunicamycin (Tuni) drugs is …
polymersome codelivering hydroxychloroquine (HCQ) and tunicamycin (Tuni) drugs is …