Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were
originally thought to be intracellular signaling pathways that mediate cytokine signals in …

More than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis,
induce inflammation and control the immune response. Cytokines are secreted …

Summary Rewiring exhausted CD8+ T (Tex) cells toward functional states remains a
therapeutic challenge. Tex cells are epigenetically programmed by the transcription factor …

Ulcerative colitis (UC) is a chronic inflammatory disease of the gastrointestinal tract, which is
closely related to gut barrier dysfunction. Emerging evidence shows that interleukin-22 (IL …

The common cytokine receptor γ chain, γ c, is a component of the receptors for interleukin-2
(IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene encoding γ c results in X-linked …

Natural Killer (NK) cells are cytotoxic lymphocytes of the innate immune system and play a
critical role in anti-viral and anti-tumor responses. NK cells develop in the bone marrow from …

The Signal Transducer and Activator of Transcription (STAT)-5 proteins are required in
immune regulation and homeostasis and play a crucial role in the development and function …

Natural killer (NK) cells are lymphocytes primarily involved in innate immunity and possess
important functional properties in anti-viral and anti-tumor responses; thus, these cells have …

In this era, it is axiomatic that cytokines have critical roles in cellular development and
differentiation, immune homeostasis, and host defense. Equally, dysregulation of cytokines …

Tumor-infiltrating dendritic cells (DCs) correlate with effective anticancer immunity and
improved responsiveness to anti–PD-1 checkpoint immunotherapy. However, the drivers of …