[HTML][HTML] Nanopore sequencing technology, bioinformatics and applications
Rapid advances in nanopore technologies for sequencing single long DNA and RNA
molecules have led to substantial improvements in accuracy, read length and throughput …
molecules have led to substantial improvements in accuracy, read length and throughput …
DNA methylation in mammalian development and disease
The DNA methylation field has matured from a phase of discovery and genomic
characterization to one seeking deeper functional understanding of how this modification …
characterization to one seeking deeper functional understanding of how this modification …
Multiple rereads of single proteins at single–amino acid resolution using nanopores
A proteomics tool capable of identifying single proteins would be important for cell biology
research and applications. Here, we demonstrate a nanopore-based single-molecule …
research and applications. Here, we demonstrate a nanopore-based single-molecule …
The Oxford Nanopore MinION: delivery of nanopore sequencing to the genomics community
Nanopore DNA strand sequencing has emerged as a competitive, portable technology.
Reads exceeding 150 kilobases have been achieved, as have in-field detection and …
Reads exceeding 150 kilobases have been achieved, as have in-field detection and …
Detecting DNA cytosine methylation using nanopore sequencing
In nanopore sequencing devices, electrolytic current signals are sensitive to base
modifications, such as 5-methylcytosine (5-mC). Here we quantified the strength of this effect …
modifications, such as 5-methylcytosine (5-mC). Here we quantified the strength of this effect …
Three decades of nanopore sequencing
A long-held goal in sequencing has been to use a voltage-biased nanoscale pore in a
membrane to measure the passage of a linear, single-stranded (ss) DNA or RNA molecule …
membrane to measure the passage of a linear, single-stranded (ss) DNA or RNA molecule …
DNA methylation-calling tools for Oxford Nanopore sequencing: a survey and human epigenome-wide evaluation
Background Nanopore long-read sequencing technology greatly expands the capacity of
long-range, single-molecule DNA-modification detection. A growing number of analytical …
long-range, single-molecule DNA-modification detection. A growing number of analytical …
Detection of DNA base modifications by deep recurrent neural network on Oxford Nanopore sequencing data
DNA base modifications, such as C5-methylcytosine (5mC) and N6-methyldeoxyadenosine
(6mA), are important types of epigenetic regulations. Short-read bisulfite sequencing and …
(6mA), are important types of epigenetic regulations. Short-read bisulfite sequencing and …
Review of clinical next-generation sequencing
S Yohe, B Thyagarajan - Archives of pathology & …, 2017 - meridian.allenpress.com
Context.—Next-generation sequencing (NGS) is a technology being used by many
laboratories to test for inherited disorders and tumor mutations. This technology is new for …
laboratories to test for inherited disorders and tumor mutations. This technology is new for …
[HTML][HTML] Benchmarking of Nanopore R10. 4 and R9. 4.1 flow cells in single-cell whole-genome amplification and whole-genome shotgun sequencing
Third-generation sequencing can be used in human cancer genomics and epigenomic
research. Oxford Nanopore Technologies (ONT) recently released R10. 4 flow cell, which …
research. Oxford Nanopore Technologies (ONT) recently released R10. 4 flow cell, which …