OBJECTIVE: Studies of the neurobiological processes underlying drug addiction primarily
have focused on limbic subcortical structures. Here the authors evaluated the role of frontal …

Neural mechanisms of cognitive control enable us to initiate, coordinate and update
behaviour. Central to successful control is the ability to suppress actions that are no longer …

Results We report accuracy rather than speed because, for young children, accuracy is the
more sensitive measure (23). We conducted multiple regression analyses with age, gender …

This volume (one of two) is the first presentation of Schore's comprehensive theory in book
form, as it has developed since 1994. In 1994 Allan Schore published his groundbreaking …

Neurophysiologic processes underlie the uncontrolled, compulsive behaviors defining the
addicted state. These “hard-wired” changes in the brain are considered critical for the …

Cocaine abusers demonstrate faulty decision-making as manifested by their inability to
discontinue self-destructive drug-seeking behaviors. The orbitofrontal cortex (OFC) plays an …

The reinforcing (rewarding) effects of psychomotor stimulants (cocaine and amphetamine)
depend on the mesocorticolimbic dopamine system innervating the nucleus accumbens …

On a decision-making instrument known as the “gambling task”(GT), a subgroup of
substance dependent individuals (SDI) opted for choices that yield high immediate gains in …

Drug addiction is characterized by a set of recurring processes (intoxication, withdrawal,
craving) that lead to the relapsing nature of the disorder. We have used positron emission …

Using a GO-NOGO response inhibition task in which working memory (WM) demands can
be varied, we demonstrate that the compromised abilities of cocaine users to exert control …