Endocannabinoids and related N-acylethanolamines: biological activities and metabolism

K Tsuboi, T Uyama, Y Okamoto, N Ueda - Inflammation and Regeneration, 2018 - Springer
The plant Cannabis sativa contains cannabinoids represented by Δ 9-tetrahydrocannabinol,
which exert psychoactivity and immunomodulation through cannabinoid CB1 and CB2 …

Palmitoylethanolamide: a natural compound for health management

P Clayton, M Hill, N Bogoda, S Subah… - International journal of …, 2021 - mdpi.com
All nations which have undergone a nutrition transition have experienced increased
frequency and falling latency of chronic degenerative diseases, which are largely driven by …

Cytokine storm syndrome in SARS-CoV-2 infections: a functional role of mast cells

B Hafezi, L Chan, JP Knapp, N Karimi, K Alizadeh… - Cells, 2021 - mdpi.com
Cytokine storm syndrome is a cascade of escalated immune responses disposing the
immune system to exhaustion, which might ultimately result in organ failure and fatal …

Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti‐inflammatory agent

F Borrelli, B Romano, S Petrosino… - British journal of …, 2015 - Wiley Online Library
Background and Purpose Palmitoylethanolamide (PEA) acts via several targets, including
cannabinoid CB 1 and CB2 receptors, transient receptor potential vanilloid type‐1 (TRPV1) …

Isolation and characterization of N‐(2‐Hydroxyethyl)hexadecanamide from Colletotrichum gloeosporioides with apoptosis‐inducing potential in breast cancer cells

N Rai, P Gupta, A Verma, SK Singh, V Gautam - BioFactors, 2023 - Wiley Online Library
Endophytic fungi are a well‐established reservoir of bioactive compounds that are
pharmaceutically valuable and therefore, contribute significantly to the biomedical field. The …

Palmitoylethanolamide (PEA) inhibits SARS-CoV-2 entry by interacting with S protein and ACE-2 receptor

R Fonnesu, VBSC Thunuguntla, GK Veeramachaneni… - Viruses, 2022 - mdpi.com
Lipids play a crucial role in the entry and egress of viruses, regardless of whether they are
naked or enveloped. Recent evidence shows that lipid involvement in viral infection goes …

Brain foods-the role of diet in brain performance and health

B Ekstrand, N Scheers, MK Rasmussen… - Nutrition …, 2021 - academic.oup.com
The performance of the human brain is based on an interplay between the inherited
genotype and external environmental factors, including diet. Food and nutrition, essential in …

Therapeutic potential of nutraceuticals and dietary supplements in the prevention of viral diseases: A review

S Singh, P Kola, D Kaur, G Singla, V Mishra… - Frontiers in …, 2021 - frontiersin.org
Nowadays, despite enormous scientific advances, viral diseases remain the leading cause
of morbidity worldwide, and their potential to spread is escalating, eventually turning into …

Endocannabinoid system and its regulation by polyunsaturated fatty acids and full spectrum hemp oils

S Komarnytsky, T Rathinasabapathy, C Wagner… - International Journal of …, 2021 - mdpi.com
The endocannabinoid system (ECS) consists of endogenous cannabinoids, their receptors,
and metabolic enzymes that play a critical homeostatic role in modulating polyunsaturated …

Antineuropathic Profile of N-Palmitoylethanolamine in a Rat Model of Oxaliplatin-Induced Neurotoxicity

L Di Cesare Mannelli, A Pacini, F Corti, S Boccella… - PloS one, 2015 - journals.plos.org
Neurotoxicity is a main side effect of the anticancer drug oxaliplatin. The development of a
neuropathic syndrome impairs quality of life and potentially results in chemotherapy dose …