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Toll-like receptor signaling and its role in cell-mediated immunity
Innate immunity is the first defense system against invading pathogens. Toll-like receptors
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …
Toll-like receptors in immunity and inflammatory diseases: Past, present, and future
K Vijay - International immunopharmacology, 2018 - Elsevier
The immune system is a very diverse system of the host that evolved during evolution to
cope with various pathogens present in the vicinity of environmental surroundings inhabited …
cope with various pathogens present in the vicinity of environmental surroundings inhabited …
Control of adaptive immunity by pattern recognition receptors
One of the most significant conceptual advances in immunology in recent history is the
recognition that signals from the innate immune system are required for induction of …
recognition that signals from the innate immune system are required for induction of …
The activation of bystander CD8+ T cells and their roles in viral infection
During viral infections, significant numbers of T cells are activated in a T cell receptor-
independent and cytokine-dependent manner, a phenomenon referred to as “bystander …
independent and cytokine-dependent manner, a phenomenon referred to as “bystander …
Application of toll-like receptors (TLRs) and their agonists in cancer vaccines and immunotherapy
Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) expressed in various
immune cell types and perform multiple purposes and duties involved in the induction of …
immune cell types and perform multiple purposes and duties involved in the induction of …
TLR agonists: our best frenemy in cancer immunotherapy
S Kaczanowska, AM Joseph… - Journal of leukocyte …, 2013 - academic.oup.com
Review on the ability of different TLR agonists to orchestrate antitumor immune responses,
or promote tumor growth, underscoring the impact of choosing among TLR agonists when …
or promote tumor growth, underscoring the impact of choosing among TLR agonists when …
TLR-dependent T cell activation in autoimmunity
KHG Mills - Nature Reviews Immunology, 2011 - nature.com
Autoimmune disease can develop as a result of a breakdown in immunological tolerance,
leading to the activation of self-reactive T cells. There is an established link between …
leading to the activation of self-reactive T cells. There is an established link between …
Toll‐Like Receptor‐Based Strategies for Cancer Immunotherapy
Toll‐like receptors (TLRs) are expressed and play multiple functional roles in a variety of
immune cell types involved in tumor immunity. There are plenty of data on the …
immune cell types involved in tumor immunity. There are plenty of data on the …
TLR-mediated metabolic reprogramming in the tumor microenvironment: potential novel strategies for cancer immunotherapy
L Huang, H Xu, G Peng - Cellular & molecular immunology, 2018 - nature.com
Cellular energy metabolism not only promotes tumor cell growth and metastasis but also
directs immune cell survival, proliferation and the ability to perform specific and functional …
directs immune cell survival, proliferation and the ability to perform specific and functional …
Toll-like receptor 2 signaling in CD4+ T lymphocytes promotes T helper 17 responses and regulates the pathogenesis of autoimmune disease
Toll-like receptors (TLRs) have previously been shown to play critical roles in the activation
of innate immunity. Here, we describe that T cell expression of TLR2 regulates T helper 17 …
of innate immunity. Here, we describe that T cell expression of TLR2 regulates T helper 17 …