Toll-like receptor signaling and its role in cell-mediated immunity

T Duan, Y Du, C **ng, HY Wang, RF Wang - Frontiers in immunology, 2022 - frontiersin.org
Innate immunity is the first defense system against invading pathogens. Toll-like receptors
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …

Toll-like receptors in immunity and inflammatory diseases: Past, present, and future

K Vijay - International immunopharmacology, 2018 - Elsevier
The immune system is a very diverse system of the host that evolved during evolution to
cope with various pathogens present in the vicinity of environmental surroundings inhabited …

Control of adaptive immunity by pattern recognition receptors

SL Carroll, C Pasare, GM Barton - Immunity, 2024 - cell.com
One of the most significant conceptual advances in immunology in recent history is the
recognition that signals from the innate immune system are required for induction of …

The activation of bystander CD8+ T cells and their roles in viral infection

TS Kim, EC Shin - Experimental & molecular medicine, 2019 - nature.com
During viral infections, significant numbers of T cells are activated in a T cell receptor-
independent and cytokine-dependent manner, a phenomenon referred to as “bystander …

Application of toll-like receptors (TLRs) and their agonists in cancer vaccines and immunotherapy

S Chakraborty, J Ye, H Wang, M Sun, Y Zhang… - Frontiers in …, 2023 - frontiersin.org
Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) expressed in various
immune cell types and perform multiple purposes and duties involved in the induction of …

TLR agonists: our best frenemy in cancer immunotherapy

S Kaczanowska, AM Joseph… - Journal of leukocyte …, 2013 - academic.oup.com
Review on the ability of different TLR agonists to orchestrate antitumor immune responses,
or promote tumor growth, underscoring the impact of choosing among TLR agonists when …

TLR-dependent T cell activation in autoimmunity

KHG Mills - Nature Reviews Immunology, 2011 - nature.com
Autoimmune disease can develop as a result of a breakdown in immunological tolerance,
leading to the activation of self-reactive T cells. There is an established link between …

Toll‐Like Receptor‐Based Strategies for Cancer Immunotherapy

S Pahlavanneshan, A Sayadmanesh… - Journal of …, 2021 - Wiley Online Library
Toll‐like receptors (TLRs) are expressed and play multiple functional roles in a variety of
immune cell types involved in tumor immunity. There are plenty of data on the …

TLR-mediated metabolic reprogramming in the tumor microenvironment: potential novel strategies for cancer immunotherapy

L Huang, H Xu, G Peng - Cellular & molecular immunology, 2018 - nature.com
Cellular energy metabolism not only promotes tumor cell growth and metastasis but also
directs immune cell survival, proliferation and the ability to perform specific and functional …

Toll-like receptor 2 signaling in CD4+ T lymphocytes promotes T helper 17 responses and regulates the pathogenesis of autoimmune disease

JM Reynolds, BP Pappu, J Peng, GJ Martinez, Y Zhang… - Immunity, 2010 - cell.com
Toll-like receptors (TLRs) have previously been shown to play critical roles in the activation
of innate immunity. Here, we describe that T cell expression of TLR2 regulates T helper 17 …