Background: Deep brain stimulation (DBS) is a highly efficient, evidence-based therapy to
alleviate symptoms and improve quality of life in movement disorders such as Parkinson's …

Control of actions allows adaptive, goal-directed behaviour. The basal ganglia, including the
subthalamic nucleus, are thought to play a central role in dynamically controlling actions …

Our decisions are guided by how we perceive the value of an option, but this evaluation also
affects how we move to acquire that option. Why should economic variables such as reward …

Adapting actions to changing goals and environments is central to intelligent behavior.
There is evidence that the basal ganglia play a crucial role in reinforcing or adapting actions …

Increasing evidence suggests a considerable role of pre-movement beta bursts for motor
control and its impairment in Parkinson's disease. However, whether beta bursts occur …

There is mounting evidence that decision-making can be affected by treatment in
Parkinson's disease. A new study shows that dopamine and deep brain stimulation, two …

The speed at which we move is linked to the speed at which we decide to make these
movements. Yet the principles guiding such relationship remain unclear: whereas some …

Humans daily life is characterized by a succession of voluntary actions. Since energy
resources are limited, the ability to invest the appropriate amount of effort for selecting and …

Background Neuroinflammation affects brain tissue integrity in multiple sclerosis (MS) and
may have a role in major depressive disorder (MDD). Whether advanced magnetic …

The ability to use past learned experiences to guide decisions is an important component of
adaptive behavior, especially when decision-making is performed under time pressure or …