The cilium is a complex organelle, the assembly of which requires the coordination of motor-
driven intraflagellar transport (IFT), membrane trafficking and selective import of cilium …

The motile and sensory functions of cilia and flagella are indispensable for human health.
Cilia assembly requires a dedicated protein shuttle, intraflagellar transport (IFT), a …

Hereditary degenerations of the human retina are genetically heterogeneous, with well over
100 genes implicated so far. This Seminar focuses on the subset of diseases called retinitis …

Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land
plants over 1 billion years ago. It is a model system for studying chloroplast-based …

Primary cilium dysfunction underlies the pathogenesis of Bardet-Biedl syndrome (BBS), a
genetic disorder whose symptoms include obesity, retinal degeneration, and nephropathy …

C. elegans has a highly developed chemosensory system that enables it to detect a wide
variety of volatile (olfactory) and water-soluble (gustatory) cues associated with food …

Cilia and flagella are ancient, evolutionarily conserved organelles that project from cell
surfaces to perform diverse biological roles, including whole-cell locomotion; movement of …

This paper presents the 12th update of the human obesity gene map, which incorporates
published results up to the end of October 2005. Evidence from single‐gene mutation …

The BBSome is a complex of Bardet-Biedl Syndrome (BBS) proteins that shares common
structural elements with COPI, COPII, and clathrin coats. Here, we show that the BBSome …

Intraflagellar transport (IFT) is a form of motor‐dependent cargo transport that is essential for
the assembly, maintenance, and length control of cilia, which play critical roles in motility …