Tissue regeneration from transplanted mesenchymal stromal cells (MSC) either through
transdifferentiation or cell fusion was originally proposed as the principal mechanism …

Myocardial infarction is a leading cause of death among all cardiovascular diseases. The
analysis of molecular mechanisms by which the ischemic myocardium initiates repair and …

Aging leads to increased cellular senescence and is associated with decreased potency of
tissue‐specific stem/progenitor cells. Here, we have done an extensive analysis of cardiac …

Background c-kit-positive, lineage-negative cardiac stem cells (CSCs) improve post-
infarction left ventricular (LV) dysfunction when administered to animals. We undertook a …

Despite significant therapeutic advances, the prognosis of patients with heart failure (HF)
remains poor, and current therapeutic approaches are palliative in the sense that they do not …

Identifying a bona fide population of cardiac stem cells (CSCs) is a critical step for
develo** cell-based therapies for heart failure patients. Previously, cardiac c-kit+ cells …

Ischemic heart disease is the leading cause of death worldwide. Myocardial infarction
results in an irreversible loss of cardiomyocytes with subsequent adverse remodeling and …

Rationale: Myocardial infarction is a leading cause of death in developed nations, and there
remains a need for cardiac therapeutic systems that mitigate tissue damage. Cardiac …

Animal and preliminary human studies of adult cell therapy following acute myocardial
infarction have shown an overall improvement of cardiac function. Myocardial and vascular …

Stem cells have emerged as a key element of regenerative medicine therapies due to their
inherent ability to differentiate into a variety of cell phenotypes, thereby providing numerous …