Liquid-liquid phase separation of RNA-binding proteins mediates the formation of numerous
membraneless organelles with essential cellular function. However, aberrant phase …

▪ Abstract Eukaryotic translation initiation factor 4F (eIF4F) is a protein complex that mediates
recruitment of ribosomes to mRNA. This event is the rate-limiting step for translation under …

Protein-RNA interactions are fundamental to core biological processes, such as mRNA
splicing, localization, degradation, and translation. We developed a photoreactive …

In response to environmental stress, the related RNA-binding proteins TIA-1 and TIAR
colocalize with poly (A) RNA at cytoplasmic foci that resemble the stress granules (SGs) that …

The RNA recognition motif (RRM), also known as RNA‐binding domain (RBD) or
ribonucleoprotein domain (RNP) is one of the most abundant protein domains in eukaryotes …

Messenger RNAs (mRNAs) are formed in the nuclei of eukaryotic cells extensive
posttranscriptional processing of primary transcripts of protein-coding genes (1, 2). These …

Human immunodeficiency virus type 1 (HIV-1) gene expression is modulated by both viral
and cellular factors. A regulatory element in the HIV-1 long terminal repeat known as TAR …

Formation of mRNA 3′ ends in eukaryotes requires the interaction of transacting factors
with cis-acting signal elements on the RNA precursor by two distinct mechanisms, one for …

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are thought to influence the structure
of hnRNA and participate in the processing of hnRNA to mRNA. The hnRNP U protein is an …

Most eukaryotic mRNAs are subject to considerable post-transcriptional modification,
including cap**, splicing, and polyadenylation. The process of polyadenylation adds a …