Tumor-infiltrating lymphocytes in the immunotherapy era
ST Paijens, A Vledder, M de Bruyn… - Cellular & molecular …, 2021 - nature.com
The clinical success of cancer immune checkpoint blockade (ICB) has refocused attention
on tumor-infiltrating lymphocytes (TILs) across cancer types. The outcome of immune …
on tumor-infiltrating lymphocytes (TILs) across cancer types. The outcome of immune …
Artificial intelligence as the next step towards precision pathology
Pathology is the cornerstone of cancer care. The need for accuracy in histopathologic
diagnosis of cancer is increasing as personalized cancer therapy requires accurate …
diagnosis of cancer is increasing as personalized cancer therapy requires accurate …
Neoantigen-directed immune escape in lung cancer evolution
The interplay between an evolving cancer and a dynamic immune microenvironment
remains unclear. Here we analyse 258 regions from 88 early-stage, untreated non-small-cell …
remains unclear. Here we analyse 258 regions from 88 early-stage, untreated non-small-cell …
[HTML][HTML] Spatial organization and molecular correlation of tumor-infiltrating lymphocytes using deep learning on pathology images
Beyond sample curation and basic pathologic characterization, the digitized H&E-stained
images of TCGA samples remain underutilized. To highlight this resource, we present …
images of TCGA samples remain underutilized. To highlight this resource, we present …
Pembrolizumab plus trastuzumab in trastuzumab-resistant, advanced, HER2-positive breast cancer (PANACEA): a single-arm, multicentre, phase 1b–2 trial
Background HER2-positive breast cancers usually contain large amounts of T-cell infiltrate.
We hypothesised that trastuzumab resistance in HER2-positive breast cancer could be …
We hypothesised that trastuzumab resistance in HER2-positive breast cancer could be …
[HTML][HTML] IASLC multidisciplinary recommendations for pathologic assessment of lung cancer resection specimens after neoadjuvant therapy
Currently, there is no established guidance on how to process and evaluate resected lung
cancer specimens after neoadjuvant therapy in the setting of clinical trials and clinical …
cancer specimens after neoadjuvant therapy in the setting of clinical trials and clinical …
Evolutionary characterization of lung adenocarcinoma morphology in TRACERx
T Karasaki, DA Moore, S Veeriah… - Nature medicine, 2023 - nature.com
Lung adenocarcinomas (LUADs) display a broad histological spectrum from low-grade
lepidic tumors through to mid-grade acinar and papillary and high-grade solid, cribriform …
lepidic tumors through to mid-grade acinar and papillary and high-grade solid, cribriform …
Geospatial immune variability illuminates differential evolution of lung adenocarcinoma
Remarkable progress in molecular analyses has improved our understanding of the
evolution of cancer cells toward immune escape,,,–. However, the spatial configurations of …
evolution of cancer cells toward immune escape,,,–. However, the spatial configurations of …
Functional Th1-oriented T follicular helper cells that infiltrate human breast cancer promote effective adaptive immunity
G Noël, ML Fontsa, S Garaud… - The Journal of …, 2021 - Am Soc Clin Investig
We previously demonstrated that tumor-infiltrating lymphocytes (TIL) in human breast cancer
sometimes form organized tertiary lymphoid structures (TLS) characterized by CXCL13 …
sometimes form organized tertiary lymphoid structures (TLS) characterized by CXCL13 …
The impact of the tumor microenvironment on macrophage polarization in cancer metastatic progression
Rather than primary solid tumors, metastasis is one of the hallmarks of most cancer deaths.
Metastasis is a multistage event in which cancer cells escape from the primary tumor survive …
Metastasis is a multistage event in which cancer cells escape from the primary tumor survive …