Leukemia is a hematological malignancy associated with the uncontrolled proliferation of
mutant progenitors, suppressing the production of normal blood cells. Current treatments …

Cancer is recognized as the major cause of death worldwide and the most challenging
public health issues. Tumor cells exhibit molecular adaptations and metabolic reprograming …

Over a century ago, the phenothiazine dye, methylene blue, was discovered to have both
antipsychotic and anti-cancer effects. In the 20th-century, the first phenothiazine …

Rosmarinus officinalis L.(rosemary) is an aromatic culinary herb. Native to the
Mediterranean region, it is currently cultivated worldwide. In addition to its use as a …

Hematological tumors are a group of diseases defined as the clonal proliferation of blood-
forming cells. In recent years, incidences of hematological malignancies have increased …

Background The pathogenesis of chronic myeloid leukemia (CML) is the formation of the
BCR/ABL protein, which is encoded by the bcr/abl fusion gene, possessing abnormal …

Erythropoietic protoporphyria (EPP) is a rare disease in which patients experience severe
light sensitivity. It is caused by a deficiency of ferrochelatase (FECH), the last enzyme in …

Mitochondria have pivotal roles in cellular physiology including energy metabolism, reactive
oxygen species production, Ca2+ homeostasis, and apoptosis. Altered mitochondrial …

The drugs used in the treatment of leishmaniasis show problems concerning side effects
and toxicity. As a result, the search for new actives is necessary, and natural products like …

Pancreatic cancer (PanCa) is a highly lethal disease with a poor 5 year survival rate, less
than 7%. It has a dismal prognosis, and more than 50% of cases are detected at an …