Mitochondria are cellular organelles with a major role in many cellular processes, including
not only energy production, metabolism, and calcium homeostasis but also regulated cell …

Programmed cell death (PCD) is the universal process that maintains cellular homeostasis
and regulates all living systems' development, health and disease. Out of all, apoptosis is …

Oxidative stress, a result of an overproduction and accumulation of free radicals, is the
leading cause of several degenerative diseases such as cancer, atherosclerosis …

Exposure to intense sound or noise can result in purely temporary threshold shift (TTS), or
leave a residual permanent threshold shift (PTS) along with alterations in growth functions of …

Regulated cell death (RCD) is essential for successful systemic cancer therapy. Yet, the
engagement of RCD pathways does not inevitably result in cell death. Instead, RCD …

Mitochondrial outer membrane permeabilization (MOMP) is often required for activation of
the caspase proteases that cause apoptotic cell death. Various intermembrane space (IMS) …

Although required for life, paradoxically, mitochondria are often essential for initiating
apoptotic cell death. Mitochondria regulate caspase activation and cell death through an …

Regulated, programmed cell death is crucial for all multicellular organisms. Cell death is
essential in many processes, including tissue sculpting during embryogenesis, development …

Necrosis can be induced by stimulating death receptors with tumor necrosis factor (TNF) or
other agonists; however, the underlying mechanism differentiating necrosis from apoptosis …

Recent studies have identified new roles for mitochondria in the regulation of
autoinflammatory processes. Emerging data suggests that the release of danger signals …