The past 20 years have seen the definition of human monogenic disorders and their
autoimmune phenocopies underlying either defective or enhanced type I interferon (IFN) …

The ability to mount an interferon-mediated innate immune response is essential in
protection against neurotropic viruses, but antiviral type I interferons also have neurotoxic …

Individuals with Down syndrome, the genetic condition caused by trisomy 21, exhibit strong
inter-individual variability in terms of developmental phenotypes and diagnosis of co …

Down syndrome (DS) is caused by trisomy of human chromosome 21 (Hsa21). DS is a gene
dosage disorder that results in multiple phenotypes including congenital heart defects. This …

Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), is characterized by
delayed neurodevelopment, accelerated aging, and increased risk of many co-occurring …

Down syndrome (DS), caused by trisomy 21 (T21), results in immune and metabolic
dysregulation. People with DS experience co-occurring conditions at higher rates than the …

Children with Down syndrome (DS) have a 10-to 20-fold greater predisposition to develop
acute leukemia compared to the general population, with a skew towards myeloid leukemia …

Congenital heart defects (CHDs) are frequent in children with Down syndrome (DS), caused
by trisomy of chromosome 21. However, the underlying mechanisms are poorly understood …

Down syndrome (DS), caused by the triplication of chromosome 21 (T21), is a prevalent
genetic disorder with a higher incidence of obesity. Traditional approaches have struggled …

Our understanding of human fetal cerebellum development during the late second trimester,
a critical period for the generation of astrocytes, oligodendrocytes, and unipolar brush cells …