Cisplatin is one of the most potent antitumor agents known, displaying clinical activity
against a wide variety of solid tumors. Its cytotoxic mode of action is mediated by its …

In multicellular organisms, homeostasis is maintained through a balance between cell
proliferation and cell death. Although much is known about the control of cell proliferation …

Multiple genetic changes occur during the evolution of normal cells into cancer cells. This
evolution is facilitated in cancer cells by loss of fidelity in the processes that replicate, repair …

Cyclin‐dependent kinases (cdk) play an essential role in the intracellular control of the cell
division cycle (cdc). These kinases and their regulators are frequently deregulated in human …

Apoptosis is a morphologically distinct form of programmed cell death that plays a major role
during development, homeostasis, and in many diseases including cancer, acquired …

It is 3 years since our minireview on cyclins and cancer (Hunter and Pines, 1991), and in that
time the number of connections between oncogenesis and the components that regulate the …

Caspases are a large family of evolutionarily conserved proteases found from
Caenorhabditis elegans to humans. Although the first caspase was identified as a …

In multicellular organisms, mutations in somatic cells affecting critical genes that regulate
cell proliferation and survival cause fatal cancers. Repair of the damage is one obvious …

The formation of distinct DNA fragments of oligonucleosomal size (180–200 by lengths) is a
biochemical hallmark of apoptosis in many cells. Recent observations also suggest large …

The Vpr accessory gene product of human immunodeficiency virus types 1 and 2 and simian
immunodeficiency virus is believed to play a role in permitting entry of the viral core into the …