Mutations in the epidermal growth factor receptor (EGFR) gene are commonly observed in
non-small-cell lung cancer (NSCLC), particularly in tumors of adenocarcinoma (ADC) …

Surgery remains the only potentially curative modality for early-stage non-small cell lung
cancer (NSCLC) patients and tissue availability is made possible. However, a proportion of …

Non-small cell lung cancer (NSCLC) accounts for> 80% of lung cancer cases and currently
has an overall five-year survival rate of only 15%. Patients presenting with advanced stage …

Chemokines, small pro-inflammatory chemoattractant cytokines that bind to specific G-
protein-coupled seven-span transmembrane receptors, are major regulators of cell …

Chemokines have fundamental roles in regulating immune and inflammatory responses,
primarily through their control of leukocyte migration and localization. The biological …

Chemokines and their receptors play a key role in development and homeostasis as well as
in the pathogenesis of tumors and autoimmune diseases. Chemokines are involved in the …

G protein-coupled receptor hetero-oligomerization is emerging as an important regulator of
ligand-dependent transmembrane signaling, but precisely how receptor heteromers affect …

Chemokines are a key component of cancer-related inflammation. Chemokines and
chemokine receptors are downstream of genetic events that cause neoplastic transformation …

Lung cancer persists to contribute to one-quarter of cancer-associated deaths. Among the
different histologies, non-small cell lung cancer (NSCLC) alone accounts for 85% of the …

Chemokines are key players in the attraction and activation of leukocytes and are thus
implicated in the recruitment of immune cells at sites of infection and/or inflammation. They …