Multiscale computational modeling of vascular adaptation: a systems biology approach using agent-based models

A Corti, M Colombo, F Migliavacca… - … in Bioengineering and …, 2021 - frontiersin.org
The widespread incidence of cardiovascular diseases and associated mortality and
morbidity, along with the advent of powerful computational resources, have fostered an …

Integrating computational and biological hemodynamic approaches to improve modeling of atherosclerotic arteries

TNAM Vuong, M Bartolf‐Kopp, K Andelovic… - Advanced …, 2024 - Wiley Online Library
Atherosclerosis is the primary cause of cardiovascular disease, resulting in mortality,
elevated healthcare costs, diminished productivity, and reduced quality of life for individuals …

[HTML][HTML] CircHIPK3 targets DRP1 to mediate hydrogen peroxide-induced necroptosis of vascular smooth muscle cells and atherosclerotic vulnerable plaque formation

X Li, Y Yang, Z Wang, X Lin, X Fu, X He, M Liu… - Journal of advanced …, 2024 - Elsevier
Introduction Necroptosis triggered by H 2 O 2 is hypothesized to be a critical factor in the
rupture of atherosclerotic plaques, which may precipitate acute cardiovascular events …

The story of wall shear stress in coronary artery atherosclerosis: biochemical transport and mechanotransduction

M Mahmoudi, A Farghadan… - Journal of …, 2021 - asmedigitalcollection.asme.org
Coronary artery atherosclerosis is a local, multifactorial, complex disease, and the leading
cause of death in the US. Complex interactions between biochemical transport and …

Wall shear stress exposure time: a Lagrangian measure of near-wall stagnation and concentration in cardiovascular flows

A Arzani, AM Gambaruto, G Chen… - … and modeling in …, 2017 - Springer
Near-wall transport is of utmost importance in connecting blood flow mechanics with
cardiovascular disease progression. The near-wall region is the interface for biologic and …

Modeling of the early stage of atherosclerosis with emphasis on the regulation of the endothelial permeability

T Silva, W Jäger, M Neuss-Radu, A Sequeira - Journal of Theoretical …, 2020 - Elsevier
In this paper, we develop a mathematical model for the early stage of atherosclerosis, as a
chronic inflammatory disease. It includes also processes that are relevant for the” thickening” …

A multiphysics modeling approach for in-stent restenosis: Theoretical aspects and finite element implementation

K Manjunatha, M Behr, F Vogt, S Reese - Computers in Biology and …, 2022 - Elsevier
Abstract Development of in silico models that capture progression of diseases in soft
biological tissues are intrinsic in the validation of the hypothesized cellular and molecular …

Mathematical modelling and simulation of atherosclerosis formation and progress: a review

NA Avgerinos, P Neofytou - Annals of Biomedical Engineering, 2019 - Springer
Cardiovascular disease (CVD) is a major threat to human health since it is the leading cause
of death in western countries. Atherosclerosis is a type of CVD related to hypertension …

Simulation of atherosclerotic plaque growth using computational biomechanics and patient-specific data

DS Pleouras, AI Sakellarios, P Tsompou, V Kigka… - Scientific Reports, 2020 - nature.com
Atherosclerosis is the one of the major causes of mortality worldwide, urging the need for
prevention strategies. In this work, a novel computational model is developed, which is used …

Bifurcation and dynamics in a mathematical model of early atherosclerosis: How acute inflammation drives lesion development

AD Chalmers, A Cohen, CA Bursill… - Journal of mathematical …, 2015 - Springer
We present here a mathematical model describing the primary mechanisms that drive the
early stages of atherosclerosis. This involves the interactions between modified low density …