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Late-stage functionalization for improving drug-like molecular properties
The development of late-stage functionalization (LSF) methodologies, particularly C–H
functionalization, has revolutionized the field of organic synthesis. Over the past decade …
functionalization, has revolutionized the field of organic synthesis. Over the past decade …
Borrowing hydrogen for organic synthesis
BG Reed-Berendt, DE Latham, MB Dambatta… - ACS central …, 2021 - ACS Publications
Borrowing hydrogen is a process that is used to diversify the synthetic utility of commodity
alcohols. A catalyst first oxidizes an alcohol by removing hydrogen to form a reactive …
alcohols. A catalyst first oxidizes an alcohol by removing hydrogen to form a reactive …
Recent advances in sustainable N-heterocyclic carbene-Pd (II)-pyridine (PEPPSI) catalysts: A review
Various catalysts in homogeneous or heterogeneous catalysis deploy unconventional
reaction pathways by lowering the activation energy (AE) barrier, controlling the selectivity …
reaction pathways by lowering the activation energy (AE) barrier, controlling the selectivity …
Trihaloisocyanuric acids in ethanol: an eco-friendly system for the regioselective halogenation of imidazo-heteroarenes
JSS Neto, RA Balaguez, MS Franco… - Green …, 2020 - pubs.rsc.org
Herein, we describe an efficient, rapid and benign protocol for the direct C (sp2)–H bond
halogenation (Cl, Br, I) of 2-arylimidazo [1, 2-a] pyridines using trihaloisocyanuric acids in …
halogenation (Cl, Br, I) of 2-arylimidazo [1, 2-a] pyridines using trihaloisocyanuric acids in …
Aryl fluorosulfates: powerful and versatile partners in cross-coupling reactions
Aryl fluorosulfates are versatile building blocks in organic synthesis and have gained
increasing attention in SuFEx (Sulfur Fluoride Exchange) click chemistry. They are easily …
increasing attention in SuFEx (Sulfur Fluoride Exchange) click chemistry. They are easily …
A ligand-free direct heteroarylation approach for benzodithiophenedione-based simple small molecular acceptors toward high efficiency polymer solar cells
Z Wu, Y Chen, L Zhang, D Yuan, R Qiu… - Journal of Materials …, 2021 - pubs.rsc.org
The development of nonfullerene acceptors has accelerated the improvement in the power
conversion efficiencies (PCEs) of polymer solar cells (PSCs) in the past five years. However …
conversion efficiencies (PCEs) of polymer solar cells (PSCs) in the past five years. However …
Pd (5%)-KIT-6, Pd (5%)-SBA-15 and Pd (5%)-SBA-16 catalysts in water extract of pomegranate ash: A case study in heterogenization of Suzuki-Miyaura reaction …
J Lakshmidevi, V Vakati, BR Naidu… - Sustainable Chemistry …, 2021 - Elsevier
Abstract Real heterogenization of Suzuki-Miyaura cross-coupling (SMC) is arduous quest
owing to unavoidable homogeneous mechanism of heterogeneous catalysts. This article …
owing to unavoidable homogeneous mechanism of heterogeneous catalysts. This article …
Palladium‐Catalyzed Electrophilic Functionalization of Pyridine Derivatives through Phosphonium Salts
YY Che, Y Yue, LZ Lin, B Pei, X Deng… - Angewandte Chemie …, 2020 - Wiley Online Library
Herein, we report a highly efficient and practical method for pyridine‐derived heterobiaryl
synthesis through palladium‐catalyzed electrophilic functionalization of easily available …
synthesis through palladium‐catalyzed electrophilic functionalization of easily available …
Electrochemically Enabled C4–H and C3–H Functionalization of 2-Phenyl Quinazoline and Quinoxaline through Dehydrogenative C–H/C–H, C–H/P–H, and C–H/O …
RD Mandal, M Saha, D Das… - The Journal of Organic …, 2023 - ACS Publications
Quinazoline moieties and particularly C4-substituted quinazoline scaffolds are widely
distributed in biologically active molecules, and thus, direct C4-functionalization of …
distributed in biologically active molecules, and thus, direct C4-functionalization of …
Bimetallic Pd–Ag nanoclusters decorated micro-cellulose bio-template towards efficient catalytic Suzuki–Miyaura coupling reaction of nitrogen-rich heterocycles
Cellulose fibers (width 8 μm) were extracted from the waste feedstock of pomegranate peels
in a simple filtration method using a water–ethanol system, without any harsh chemical pre …
in a simple filtration method using a water–ethanol system, without any harsh chemical pre …