Beyond addressing technological demands, the integration of machine learning (ML) into
human societies has also promoted sustainability through the adoption of digitalized …

Recent years have witnessed the transformative impact from the integration of artificial
intelligence with organic and polymer synthesis. This synergy offers innovative and …

The borylation of aryl and heteroaryl C–H bonds is valuable for the site-selective
functionalization of C–H bonds in complex molecules. Iridium catalysts ligated by bipyridine …

Optimization of the catalyst structure to simultaneously improve multiple reaction objectives
(eg, yield, enantioselectivity, and regioselectivity) remains a formidable challenge. Herein …

Late-stage functionalization is an economical approach to optimize the properties of drug
candidates. However, the chemical complexity of drug molecules often makes late-stage …

Acylsilanes are emerging bench-stable reagents for the generation of electron-rich
oxycarbenes that are difficult to access with unstable diazo compounds. Herein, we report a …

The rapid and precise creation of complex molecules while controlling multiple selectivities
is the principal objective in synthetic chemistry. Combining data science and organic …

The exponential proliferation of conformers makes it impossible to examine the entire
population in most systems. Controlling conformational ensembles is thus pivotal in many …

Selective functionalization of non‐activated C (sp3)− H bonds is a major challenge in
chemistry, so functional groups are often used to enhance reactivity. Here, we present a gold …

The application of mechanistic generalizations is at the core of chemical reaction
development and application. These strategies are rooted in physical organic chemistry …