Non-coding RNA in the wiring and remodeling of neural circuits

M Soutschek, G Schratt - Neuron, 2023 - cell.com
The brain constantly adapts to changes in the environment, a capability that underlies
memory and behavior. Long-term adaptations require the remodeling of neural circuits that …

Epigenetic mechanisms underlying sex differences in the brain and behavior

M Kundakovic, M Tickerhoof - Trends in neurosciences, 2024 - cell.com
Sex differences are found across brain regions, behaviors, and brain diseases. Sexual
differentiation of the brain is initiated prenatally but it continues throughout life, as a result of …

Sex differences in stress response: Classical mechanisms and beyond

GE Hodes, D Bangasser, I Sotiropoulos… - Current …, 2024 - benthamdirect.com
Neuropsychiatric disorders, which are associated with stress hormone dysregulation, occur
at different rates in men and women. Moreover, nowadays, preclinical and clinical evidence …

Epigenetic mechanisms of rapid-acting antidepressants

A Inserra, A Campanale, T Rezai, P Romualdi… - Translational …, 2024 - nature.com
Abstract Background Rapid-acting antidepressants (RAADs), including dissociative
anesthetics, psychedelics, and empathogens, elicit rapid and sustained therapeutic …

Noncoding RNAs: emerging regulators of behavioral complexity

S Dayal, D Chaubey, DC Joshi… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
The mammalian genome encodes thousands of non− coding RNAs (ncRNAs), ranging in
size from about 20 nucleotides (microRNAs or miRNAs) to kilobases (long non− coding …

SNORA69 is up-regulated in the lateral habenula of individuals with major depressive disorder

R Lin, H Mitsuhashi, LM Fiori, R Denniston… - Scientific Reports, 2024 - nature.com
Major depressive disorder (MDD) is a complex and potentially debilitating illness whose
etiology and pathology remains unclear. Non-coding RNAs have been implicated in MDD …

Epigenetic mechanisms in depression: implications for pathogenesis and treatment

HS Chen, F Wang, JG Chen - Current Opinion in Neurobiology, 2024 - Elsevier
The risk of depression is influenced by both genetic and environmental factors. It has been
suggested that epigenetic mechanisms may mediate the risk of depression following …

Male and female behavioral variability and morphine response in C57BL/6J, DBA/2J, and their BXD progeny following chronic stress exposure

C Morel, LF Parise, YY Van der Zee, O Issler, M Cai… - Scientific Reports, 2024 - nature.com
Drug addiction is a multifactorial syndrome in which genetic predispositions and exposure to
environmental stressors constitute major risk factors for the early onset, escalation, and …

Identification of potential biomarkers for major depressive disorder: based on integrated bioinformatics and clinical validation

X Zhong, Y Chen, W Chen, Y Liu, S Gui, J Pu… - Molecular …, 2024 - Springer
Major depressive disorder (MDD) is a severe mental illness characterized by a lack of
objective biomarkers. Mounting evidence suggests there are extensive transcriptional …

Unique spatially and temporary-regulated/sex-specific expression of a long ncRNA, Nb-1, suggesting its pleiotropic functions associated with honey bee lifecycle

H Tadano, H Kohno, H Takeuchi, T Kubo - Scientific Reports, 2024 - nature.com
Honey bees are social insects, and each colony member has unique morphological and
physiological traits associated with their social tasks. Previously, we identified a long non …