[HTML][HTML] Methylation of the JMJD2B epigenetic regulator differentially affects its ability to coactivate the ETV1 and JUN transcription factors
TD Kim, R Gu, R Janknecht - International Journal of Biochemistry …, 2023 - ncbi.nlm.nih.gov
Objectives: Jumonji C domain-containing (JMJD) 2B (JMJD2B) is a transcriptional cofactor
and histone demethylase that is involved in prostate cancer formation. However, how its …
and histone demethylase that is involved in prostate cancer formation. However, how its …
Development and characterization of an ETV1 rabbit monoclonal antibody for the immunohistochemical detection of ETV1 expression in cancer tissue specimens
C Schafer, D Young, H Singh, R Jayakrishnan… - Journal of …, 2023 - Elsevier
Background Aberrant ETV1 overexpression arising from gene rearrangements or mutations
occur frequently in prostate cancer, round cell sarcomas, gastrointestinal stromal tumors …
occur frequently in prostate cancer, round cell sarcomas, gastrointestinal stromal tumors …
Oncogenic signaling in the adult Drosophila prostate-like accessory gland leads to activation of a conserved pro-tumorigenic program, in the absence of proliferation.
SJ Church, AJ Pulianmackal, JA Dixon, LV Loftus… - bioRxiv, 2024 - biorxiv.org
Drosophila models for tumorigenesis and metastasis have revealed conserved mechanisms
of signaling that are also involved in mammalian cancer. Many of these models use the …
of signaling that are also involved in mammalian cancer. Many of these models use the …
Multi-omic analysis of CIC's functional networks reveals novel interaction partners and a potential role in mitotic fidelity
Simple Summary Capicua (CIC) is a gene that is frequently mutated in several cancer types,
including stomach cancers and certain subtypes of brain tumours and sarcomas. CIC, the …
including stomach cancers and certain subtypes of brain tumours and sarcomas. CIC, the …
[PDF][PDF] Multi-Omic Analysis of CIC's Functional Networks Reveals Novel Interaction Partners and a Potential Role in Mitotic Fidelity. Cancers 2023, 15, 2805
Y Takemon, VG LeBlanc, J Song, SY Chan, SD Lee… - 2023 - open.library.ubc.ca
CIC encodes a transcriptional repressor and MAPK signalling effector that is inactivated by
loss-of-function mutations in several cancer types, consistent with a role as a tumour …
loss-of-function mutations in several cancer types, consistent with a role as a tumour …
Map** in silico genetic networks of tumour suppressor genes to uncover novel gene functions and predict cancer cell vulnerabilities
Y Takemon - 2024 - open.library.ubc.ca
Sequencing technologies have advanced the discovery of cancer-related genes. However,
the functional impact of mutations in these genes and the effect of their mutated forms on a …
the functional impact of mutations in these genes and the effect of their mutated forms on a …