BDNF as a promising therapeutic agent in Parkinson's disease

E Palasz, A Wysocka, A Gasiorowska… - International journal of …, 2020 - mdpi.com
Brain-derived neurotrophic factor (BDNF) promotes neuroprotection and neuroregeneration.
In animal models of Parkinson's disease (PD), BDNF enhances the survival of dopaminergic …

Physical exercise as an epigenetic modulator of brain plasticity and cognition

J Fernandes, RM Arida, F Gomez-Pinilla - Neuroscience & Biobehavioral …, 2017 - Elsevier
A large amount of evidence has demonstrated the power of exercise to support cognitive
function, the effects of which can last for considerable time. An emerging line of scientific …

BDNF and synaptic plasticity, cognitive function, and dysfunction

B Lu, G Nagappan, Y Lu - Neurotrophic factors, 2014 - Springer
Among all neurotrophins, brain-derived neurotrophic factor (BDNF) stands out for its high
level of expression in the brain and its potent effects on synapses. It is now widely accepted …

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

B Lu, G Nagappan, X Guan, PJ Nathan… - Nature Reviews …, 2013 - nature.com
Increasing evidence suggests that synaptic dysfunction is a key pathophysiological hallmark
in neurodegenerative disorders, including Alzheimer's disease. Understanding the role of …

BDNF-induced local protein synthesis and synaptic plasticity

G Leal, D Comprido, CB Duarte - Neuropharmacology, 2014 - Elsevier
Brain-derived neurotrophic factor (BDNF) is an important regulator of synaptic transmission
and long-term potentiation (LTP) in the hippocampus and in other brain regions, playing a …

Exercise influence on the microbiome–gut–brain axis

A Dalton, C Mermier, M Zuhl - Gut microbes, 2019 - Taylor & Francis
The microbiome in the gut is a diverse environment, housing the majority of our bacterial
microbes. This microecosystem has a symbiotic relationship with the surrounding …

Regulation of hippocampal synaptic plasticity by BDNF

G Leal, PM Afonso, IL Salazar, CB Duarte - Brain research, 2015 - Elsevier
The neurotrophin brain-derived neurotrophic factor (BDNF) has emerged as a major
regulator of activity-dependent plasticity at excitatory synapses in the mammalian central …

Oxidative stress in cognitive and epigenetic aging: a retrospective glance

A Kandlur, K Satyamoorthy… - Frontiers in molecular …, 2020 - frontiersin.org
Brain aging is the critical and common factor among several neurodegenerative disorders
and dementia. Cellular, biochemical and molecular studies have shown intimate links …

The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function

MF Egan, M Kojima, JH Callicott, TE Goldberg… - Cell, 2003 - cell.com
Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity and
hippocampal-dependent memory in cell models and in animals. We examined the effects of …

Brain foods: the effects of nutrients on brain function

F Gómez-Pinilla - Nature reviews neuroscience, 2008 - nature.com
It has long been suspected that the relative abundance of specific nutrients can affect
cognitive processes and emotions. Newly described influences of dietary factors on …