Understanding the human antibody repertoire
AR Rees - MAbs, 2020 - Taylor & Francis
The origins of the various elements in the human antibody repertoire have been and still are
subject to considerable uncertainty. Uncertainty in respect of whether the various elements …
subject to considerable uncertainty. Uncertainty in respect of whether the various elements …
Characterizing immune repertoires by high throughput sequencing: strategies and applications
JJA Calis, BR Rosenberg - Trends in immunology, 2014 - cell.com
As the key cellular effectors of adaptive immunity, T and B lymphocytes utilize specialized
receptors to recognize, respond to, and neutralize a diverse array of extrinsic threats. These …
receptors to recognize, respond to, and neutralize a diverse array of extrinsic threats. These …
Commonality despite exceptional diversity in the baseline human antibody repertoire
In principle, humans can produce an antibody response to any non-self-antigen molecule in
the appropriate context. This flexibility is achieved by the presence of a large repertoire of …
the appropriate context. This flexibility is achieved by the presence of a large repertoire of …
High frequency of shared clonotypes in human B cell receptor repertoires
C Soto, RG Bombardi, A Branchizio, N Kose, P Matta… - Nature, 2019 - nature.com
The human genome contains approximately 20 thousand protein-coding genes, but the size
of the collection of antigen receptors of the adaptive immune system that is generated by the …
of the collection of antigen receptors of the adaptive immune system that is generated by the …
An atlas of B-cell clonal distribution in the human body
B-cell responses result in clonal expansion, and can occur in a variety of tissues. To define
how B-cell clones are distributed in the body, we sequenced 933,427 B-cell clonal lineages …
how B-cell clones are distributed in the body, we sequenced 933,427 B-cell clonal lineages …
Reproducibility and reuse of adaptive immune receptor repertoire data
High-throughput sequencing (HTS) of immunoglobulin (B-cell receptor, antibody) and T-cell
receptor repertoires has increased dramatically since the technique was introduced in 2009 …
receptor repertoires has increased dramatically since the technique was introduced in 2009 …
Identification of near-pan-neutralizing antibodies against HIV-1 by deconvolution of plasma humoral responses
Anti-HIV-1 envelope broadly neutralizing monoclonal antibodies (bNAbs) isolated from
memory B cells may not fully represent HIV-1-neutralizing profiles measured in plasma …
memory B cells may not fully represent HIV-1-neutralizing profiles measured in plasma …
Principles of broad and potent antiviral human antibodies: insights for vaccine design
JE Crowe - Cell host & microbe, 2017 - cell.com
Antibodies are the principal immune effectors that mediate protection against reinfection
following viral infection or vaccination. Robust techniques for human mAb isolation have …
following viral infection or vaccination. Robust techniques for human mAb isolation have …
Serology in the 21st century: the molecular-level analysis of the serum antibody repertoire
Highlights•New technologies have revolutionized serological antibody analysis.•NextGen
sequencing and shotgun proteomics help identify and quantify serum mAb's.•Clonality and …
sequencing and shotgun proteomics help identify and quantify serum mAb's.•Clonality and …
The multilevel extensive diversity across the cynomolgus macaque captured by ultra-deep adaptive immune receptor repertoire sequencing
Y Zhu, H Tang, W **e, S Chen, H Zeng, C Lan… - Science …, 2024 - science.org
The extent to which AIRRs differ among and within individuals remains elusive. Via ultra-
deep repertoire sequencing of 22 and 25 tissues in three cynomolgus macaques …
deep repertoire sequencing of 22 and 25 tissues in three cynomolgus macaques …