Cancer is driven by multiple types of genetic alterations, which range in size from point
mutations to whole-chromosome gains and losses, known as aneuploidy. Chromosome …

Image-based profiling is a maturing strategy by which the rich information present in
biological images is reduced to a multidimensional profile, a collection of extracted image …

Large panels of comprehensively characterized human cancer models, including the
Cancer Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to …

Target discovery is one of the essential steps in modern drug development, and the
identification of promising targets is fundamental for develo** first-in-class drug. A variety …

Even among genetically identical cancer cells, resistance to therapy frequently emerges
from a small subset of those cells,,,,,–. Molecular differences in rare individual cells in the …

Anticancer uses of non-oncology drugs have occasionally been found, but such discoveries
have been serendipitous. We sought to create a public resource containing the growth …

Ovarian cancer (OC) is a heterogeneous disease usually diagnosed at a late stage.
Experimental in vitro models that faithfully capture the hallmarks and tumor heterogeneity of …

Highlights•Artificial Intelligence (AI) has transformed many areas such as speech and image
recognition, but not yet drug discovery.•Approaches to AI in drug discovery need to take in …

Ninety-seven percent of drug-indication pairs that are tested in clinical trials in oncology
never advance to receive US Food and Drug Administration approval. While lack of efficacy …

Glioblastomas harbor diverse cell populations, including rare glioblastoma stem cells
(GSCs) that drive tumorigenesis. To characterize functional diversity within this population …