Not the usual suspects: Alternative surfactants for biopharmaceuticals
S Brosig, S Cucuzza, T Serno… - … applied materials & …, 2023 - ACS Publications
Therapeutically relevant proteins naturally adsorb to interfaces, causing aggregation which
in turn potentially leads to numerous adverse consequences such as loss of activity or …
in turn potentially leads to numerous adverse consequences such as loss of activity or …
Characterization of recombinantly-expressed hydrolytic enzymes from chinese hamster ovary cells: identification of host cell proteins that degrade polysorbate
Enzymatic hydrolysis of polysorbate in drug products is a major challenge for the
biopharmaceutical industry. Polysorbate hydrolysis caused by host cell proteins (HCPs) co …
biopharmaceutical industry. Polysorbate hydrolysis caused by host cell proteins (HCPs) co …
A Review of Polysorbate Quantification and its Degradation Analysis by Liquid Chromatography Coupled with Charged Aerosol Detection
L Shi, G Shen, R Chai, PH Gamache, Y ** - Journal of Chromatography A, 2024 - Elsevier
Abstract Polysorbates (PS), as non-ionic surfactants, contribute significantly to the stability of
proteins in formulations. However, their lack of chromophore groups makes them difficult to …
proteins in formulations. However, their lack of chromophore groups makes them difficult to …
Existence of a superior polysorbate fraction in respect to protein stabilization and particle formation?
T Diederichs, JJ Mittag, J Humphrey, S Voss… - International Journal of …, 2023 - Elsevier
Biologicals including monoclonal antibodies are the current flagships in pharmaceutical
industry. However, they are exposed to a multitude of destabilization conditions like for …
industry. However, they are exposed to a multitude of destabilization conditions like for …
End-to-end approach to surfactant selection, risk mitigation, and control strategies for protein-based therapeutics
A survey performed by the AAPS Drug Product Handling community revealed a general,
mostly consensus, approach to the strategy for the selection of surfactant type and level for …
mostly consensus, approach to the strategy for the selection of surfactant type and level for …
Guanidine-modified albumin-MMAE conjugates with enhanced endocytosis ability
C Yi, F ** stable biopharmaceutical formulations is of paramount importance and is
typically achieved by incorporating surfactants as stabilising agents, such as polysorbate 20 …
typically achieved by incorporating surfactants as stabilising agents, such as polysorbate 20 …
[HTML][HTML] Enzymatic degradation pattern of polysorbate 20 impacts interfacial properties of monoclonal antibody formulations
Abstract Polysorbate 20 (PS20) is widely used to maintain protein stability in
biopharmaceutical formulations. However, PS20 is susceptible to hydrolytic degradation …
biopharmaceutical formulations. However, PS20 is susceptible to hydrolytic degradation …
[HTML][HTML] High throughput FAMS–A fatty acid mass spectrometry method for monitoring polysorbate hydrolysis in QC
S Hoelterhoff, J Wendler, L Arackal, B Felkel… - … of Chromatography B, 2023 - Elsevier
Surfactant degradation in biopharmaceuticals has recently gained significant attention in the
pharmaceutical industry. Specifically, hydrolytic degradation of polysorbates, leading to the …
pharmaceutical industry. Specifically, hydrolytic degradation of polysorbates, leading to the …