Thalassemia, an inherited quantitative globin disorder, consists of two types, α–and β–
thalassemia. β–thalassemia is a heterogeneous disease that can be asymptomatic, mild, or …

Abstract Heme oxygenase 1 (HO-1), encoded by the HMOX-1 gene, is the main heme
oxygenase that catalyzes the degradation of heme into iron, carbon monoxide, and …

In sickle cell disease (SCD), heme released during intravascular hemolysis promotes
oxidative stress, inflammation, and vaso-occlusion. Conversely, free heme can also activate …

Reference genes are indispensable for normalizing mRNA levels across samples in real-
time quantitative PCR. Their expression levels vary under different experimental conditions …

Since first described, sickle cell disease (SCD) has represented a therapeutic challenge for
clinicians trying to help patients enduring the ramifications of this dreadful condition. This life …

BTB domain and CNC homolog 1 (BACH1) belongs to the family of basic leucine zipper
proteins and is expressed in most mammalian tissues. It can regulate its own expression …

The large clinical spectrum of Haemoglobin E (HbE)/β-thalassaemia leads to identification of
modifiers that cause the complexity1. IGSF4, a member of the immunoglobulin superfamily 4 …

The HEF gene mutation affects iron absorption, and its genetic polymorphism is correlated
with multiple diseases. This study analyzed the correlation between HFE polymorphisms …