Diffusion magnetic resonance imaging (dMRI) tractography is an advanced imaging
technique that enables in vivo reconstruction of the brain's white matter connections at …

Recent years have seen an increased understanding of the importance of myelination in
healthy brain function and neuropsychiatric diseases. Non-invasive microstructural magnetic …

Emerging evidence suggests that altered myelination is an important pathophysiologic
correlate of several neurodegenerative diseases, including Alzheimer and Parkinson's …

Myelin is the protective sheath wrapped around axons, consisting of a phospholipid bilayer
with water between the wraps. The measurement of damage to the myelin sheaths, the …

Myelin loss and iron accumulation are cardinal features of aging and various
neurodegenerative diseases. Oligodendrocytes incorporate iron as a metabolic substrate for …

In vertebrates, oligodendrocytes (OLs) are glial cells of the central nervous system (CNS)
responsible for the formation of the myelin sheath that surrounds the axons of neurons. The …

Myelin development during adolescence is becoming an area of growing interest in view of
its potential relationship to cognition, behavior, and learning. While recent investigations …

White matter (WM) microstructural properties change across the adult lifespan and with
neuronal diseases. Understanding microstructural changes due to aging is paramount to …

Strict iron regulation is essential for normal brain function. The iron homeostasis, determined
by the milieu of available iron compounds, is impaired in aging, neurodegenerative …

Background and Objectives Myelin and iron play essential roles in remyelination processes
of multiple sclerosis (MS) lesions. χ-separation, a novel biophysical model applied to …