Utility of B-factors in protein science: interpreting rigidity, flexibility, and internal motion and engineering thermostability

Z Sun, Q Liu, G Qu, Y Feng, MT Reetz - Chemical reviews, 2019 - ACS Publications
The term B-factor, sometimes called the Debye–Waller factor, temperature factor, or atomic
displacement parameter, is used in protein crystallography to describe the attenuation of X …

Biosynthesis of fungal meroterpenoids

Y Matsuda, I Abe - Natural product reports, 2016 - pubs.rsc.org
Covering: up to September 2015 Meroterpenoids are hybrid natural products that partially
originate from the terpenoid pathway. The meroterpenoids derived from fungi display quite …

[KNJIGA][B] Hydrolases in organic synthesis: regio-and stereoselective biotransformations

UT Bornscheuer, RJ Kazlauskas - 2006 - books.google.com
From reviews to the first edtion:" Bornscheuer and Kazlauskas have set out, and succeeded,
in producing a definitive manual on hydrolytic enzymes (especially lipases, esterases, and …

Computationally designed libraries for rapid enzyme stabilization

HJ Wijma, RJ Floor, PA Jekel, D Baker… - … , Design & Selection, 2014 - academic.oup.com
The ability to engineer enzymes and other proteins to any desired stability would have wide-
ranging applications. Here, we demonstrate that computational design of a library with …

Epoxide hydrolases: their roles and interactions with lipid metabolism

JW Newman, C Morisseau, BD Hammock - Progress in lipid research, 2005 - Elsevier
The epoxide hydrolases (EHs) are enzymes present in all living organisms, which transform
epoxide containing lipids by the addition of water. In plants and animals, many of these lipid …

Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles

C Morisseau, BD Hammock - Annu. Rev. Pharmacol. Toxicol., 2005 - annualreviews.org
▪ Abstract Organisms are exposed to epoxide-containing compounds from both exogenous
and endogenous sources. In mammals, the hydration of these compounds by various …

Enzymes from extreme environments and their industrial applications

JA Littlechild - Frontiers in bioengineering and biotechnology, 2015 - frontiersin.org
This article will discuss the importance of specific extremophilic enzymes for applications in
industrial biotechnology. It will specifically address those enzymes that have applications in …

Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A

D Jiang, Y Zhao, X Wang, J Fan, J Heng, X Liu… - Proceedings of the …, 2013 - pnas.org
The major facilitator superfamily (MFS) is the largest family of secondary active transporters
and is present in all life kingdoms. Detailed structural basis of the substrate transport and …

Mammalian epoxide hydrolases in xenobiotic metabolism and signalling

M Decker, M Arand, A Cronin - Archives of toxicology, 2009 - Springer
Epoxide hydrolases catalyse the hydrolysis of electrophilic—and therefore potentially
genotoxic—epoxides to the corresponding less reactive vicinal diols, which explains the …

Enantioselective enzymes by computational design and in silico screening

HJ Wijma, RJ Floor, S Bjelic, SJ Marrink… - Angewandte Chemie …, 2015 - Wiley Online Library
Computational enzyme design holds great promise for providing new biocatalysts for
synthetic chemistry. A strategy to design small mutant libraries of complementary …