Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …

According to Darwin's theory, endless evolution leads to a revolution. One such example is
the Clustered Regularly Interspaced Palindromic Repeats (CRISPR)–Cas system, an …

Metabolic burden is defined by the influence of genetic manipulation and environmental
perturbations on the distribution of cellular resources. The rewiring of microbial metabolism …

The issues of global warming, coupled with fossil fuel depletion, have undoubtedly led to
renewed interest in other sources of commercial fuels. The search for renewable fuels has …

The worldwide utilization of fossil energy, including its specific application as transportation
fuel, significantly contributes to the continuous increase of the atmospheric CO 2 …

Engineering cell metabolism for bioproduction not only consumes building blocks and
energy molecules (eg, ATP) but also triggers energetic inefficiency inside the cell. The …

Metabolic engineering of microorganisms to produce desirable products on an industrial
scale can result in unbalanced cellular metabolic networks that reduce productivity and …

Harnessing lipogenic pathways and rewiring acyl-CoA and acyl-ACP (acyl carrier protein)
metabolism in Yarrowia lipolytica hold great potential for cost-efficient production of diesel …

Sustainable production of oleochemicals requires establishment of cell factory platform
strains. The yeast Saccharomyces cerevisiae is an attractive cell factory as new strains can …

Transcription-factor-based biosensors (TFBs) are often used for metabolite detection,
adaptive evolution, and metabolic flux control. However, designing TFBs with superior …