Tumours employ various tactics to adapt and eventually resist immune attack. These
mechanisms are collectively called adaptive immune resistance (AIR). The first defined and …

It is impossible to underplay the importance of fixation in histopathology. Whether the
scientist is interested in the extraction of information on lipids, proteins, RNA or DNA, fixation …

Global classification of the human proteins with regards to spatial expression patterns
across organs and tissues is important for studies of human biology and disease. Here, we …

Paraformaldehyde (PFA) is the most commonly used fixative for immunostaining of cells, but
has been associated with various problems, ranging from loss of antigenicity to changes in …

Identifying the building blocks of mammalian tissues is a precondition for understanding
their function. In particular, global and quantitative analysis of the proteome of mammalian …

The existence of G protein-coupled receptor (GPCR) dimers and/or oligomers has been
demonstrated in heterologous systems using a variety of biochemical and biophysical …

The tissue microarray (TMA) technology provides the means for high-throughput analysis of
multiple tissues and cells. The technique is used within the Human Protein Atlas project for …

Fixation ability of five common fixation solutions, including 2.5% glutaraldehyde, 10%
formalin, 4% paraformaldehyde, methanol/acetone (1: 1), and ethanol/acetic acid (3: 1) were …

Introduction According to mechanisms of adaptive immune resistance, tumor immune
microenvironment (TIME) is classified into four types:(1) programmed death-ligand 1 (PD …

The effective implementation of personalized cancer therapeutic regimens depends on the
successful identification and translation of informative biomarkers to aid clinical decision …