Polygenic risk scores for cardiovascular disease: a scientific statement from the American Heart Association
Cardiovascular disease is the leading contributor to years lost due to disability or premature
death among adults. Current efforts focus on risk prediction and risk factor mitigation ‚which …
death among adults. Current efforts focus on risk prediction and risk factor mitigation ‚which …
New insights into cerebrovascular pathophysiology and hypertension
Despite advances in acute management and prevention of cerebrovascular disease, stroke
and vascular cognitive impairment together remain the world's leading cause of death and …
and vascular cognitive impairment together remain the world's leading cause of death and …
[HTML][HTML] A single-cell atlas of chromatin accessibility in the human genome
Current catalogs of regulatory sequences in the human genome are still incomplete and lack
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …
Gut microbially produced indole-3-propionic acid inhibits atherosclerosis by promoting reverse cholesterol transport and its deficiency is causally related to …
H Xue, X Chen, C Yu, Y Deng, Y Zhang… - Circulation …, 2022 - Am Heart Assoc
Background: Accumulating evidence has shown that disorders in the gut microbiota and
derived metabolites affect the development of atherosclerotic cardiovascular disease …
derived metabolites affect the development of atherosclerotic cardiovascular disease …
Constrained maximum likelihood-based Mendelian randomization robust to both correlated and uncorrelated pleiotropic effects
With the increasing availability of large-scale GWAS summary data on various complex traits
and diseases, there have been tremendous interests in applications of Mendelian …
and diseases, there have been tremendous interests in applications of Mendelian …
Associations of combined genetic and lifestyle risks with incident cardiovascular disease and diabetes in the UK Biobank Study
Importance Genetic and lifestyle factors both contribute to the risk of develo**
cardiovascular disease, but whether poor health behaviors are associated with similar …
cardiovascular disease, but whether poor health behaviors are associated with similar …
The Mediterranean diet, plasma metabolome, and cardiovascular disease risk
Aims To investigate whether metabolic signature composed of multiple plasma metabolites
can be used to characterize adherence and metabolic response to the Mediterranean diet …
can be used to characterize adherence and metabolic response to the Mediterranean diet …
Polycystic ovary syndrome and risk of type 2 diabetes, coronary heart disease, and stroke
T Zhu, J Cui, MO Goodarzi - Diabetes, 2021 - Am Diabetes Assoc
Polycystic ovary syndrome (PCOS) has been associated with diabetes and cardiovascular
disease; however, whether the relationship is causal is uncertain. We conducted a two …
disease; however, whether the relationship is causal is uncertain. We conducted a two …
Genetically determined levels of circulating cytokines and risk of stroke: role of monocyte chemoattractant protein-1
Background: Cytokines and growth factors have been implicated in the initiation and
propagation of vascular disease. Observational studies have shown associations of their …
propagation of vascular disease. Observational studies have shown associations of their …
Urate, blood pressure, and cardiovascular disease: evidence from mendelian randomization and meta-analysis of clinical trials
Serum urate has been implicated in hypertension and cardiovascular disease, but it is not
known whether it is exerting a causal effect. To investigate this, we performed Mendelian …
known whether it is exerting a causal effect. To investigate this, we performed Mendelian …