Multivalent interactions can be applied universally for a targeted strengthening of an
interaction between different interfaces or molecules. The binding partners form cooperative …

Department of Pharmaceutical Chemistry, University of California, San Francisco, California
94143-1204 Received April 3, 1990; Revised Manuscript Received May 2, 1990 e purpose …

The understanding, and even the description of protein folding is impeded by the complexity
of the process. Much of this complexity can be described and understood by taking a …

▪ Abstract The energy landscape theory of protein folding is a statistical description of a
protein's potential surface. It assumes that folding occurs through organizing an ensemble of …

A lattice model of protein folding is developed to distinguish between amino acid sequences
that do and do not fold into unique conformations. Although Monte Carlo simulations provide …

Attractive inter-residue contact energies for proteins have been re-evaluated with the same
assumptions and approximations used originally by us in 1985, but with a significantly larger …

An amino acid sequence encodes a message that determines the shape and function of a
protein. This message is highly degenerate in that many different sequences can code for …

General principles of protein structure, stability, and folding kinetics have recently been
explored in computer simulations of simple exact lattice models. These models represent …

We estimated effective atomic contact energies (ACE), the desolvation free energies
required to transfer atoms from water to a protein's interior, using an adaptation of a method …

Computation based on molecular models is playing an increasingly important role in
biology, biological chemistry, and biophysics. Since only a very limited number of properties …