[HTML][HTML] Beyond repression of Nrf2: An update on Keap1
Abstract Nrf2 (NFE2L2–nuclear factor (erythroid-derived 2)-like 2) is a transcription factor,
which is repressed by interaction with a redox-sensitive protein Keap1 (Kelch-like ECH …
which is repressed by interaction with a redox-sensitive protein Keap1 (Kelch-like ECH …
[HTML][HTML] Fuzzy complexes: Specific binding without complete folding
Specific molecular recognition is assumed to require a well-defined set of contacts and
devoid of conformational and interaction ambiguities. Growing experimental evidence …
devoid of conformational and interaction ambiguities. Growing experimental evidence …
Extreme disorder in an ultrahigh-affinity protein complex
Molecular communication in biology is mediated by protein interactions. According to the
current paradigm, the specificity and affinity required for these interactions are encoded in …
current paradigm, the specificity and affinity required for these interactions are encoded in …
AlphaFold2: a role for disordered protein/region prediction?
The development of AlphaFold2 marked a paradigm-shift in the structural biology
community. Herein, we assess the ability of AlphaFold2 to predict disordered regions …
community. Herein, we assess the ability of AlphaFold2 to predict disordered regions …
Fuzziness in protein interactions—a historical perspective
M Fuxreiter - Journal of molecular biology, 2018 - Elsevier
The proposal that coupled folding to binding is not an obligatory mechanism for intrinsically
disordered (ID) proteins was put forward 10 years ago. The notion of fuzziness implies that …
disordered (ID) proteins was put forward 10 years ago. The notion of fuzziness implies that …
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation
Y Qiao, L Xu, X Tao, L Yin, Y Qi, Y Xu, X Han, Z Tang… - Toxicology letters, 2018 - Elsevier
In the present work, the effects and possible mechanisms of dioscin, one natural product
from the famous vegetable Dioscoreae rhizoma (Shanyao in Chinese), against high fructose …
from the famous vegetable Dioscoreae rhizoma (Shanyao in Chinese), against high fructose …
Mass spectrometry methods for studying structure and dynamics of biological macromolecules
All processes that occur within living organisms are intimately linked to biological
macromolecules such as proteins, nucleic acids, or polysaccharides. Phospholipid …
macromolecules such as proteins, nucleic acids, or polysaccharides. Phospholipid …
Emerging substrate proteins of kelch-like ECH associated protein 1 (Keap1) and potential challenges for the development of small-molecule inhibitors of the Keap1 …
Y Zhang, Z Shi, Y Zhou, Q **ao, H Wang… - Journal of Medicinal …, 2020 - ACS Publications
The activation of nuclear factor erythroid 2-related factor 2 (Nrf2) is believed to combat both
oxidative stress and inflammation as a promising strategy to treat chronic diseases …
oxidative stress and inflammation as a promising strategy to treat chronic diseases …
Nrf2, the major regulator of the cellular oxidative stress response, is partially disordered
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription regulator that plays a
pivotal role in coordinating the cellular response to oxidative stress. Through interactions …
pivotal role in coordinating the cellular response to oxidative stress. Through interactions …
Mutual population-shift driven antibody-peptide binding elucidated by molecular dynamics simulations
GJ Bekker, I Fukuda, J Higo, N Kamiya - Scientific Reports, 2020 - nature.com
Antibody based bio-molecular drugs are an exciting, new avenue of drug development as
an alternative to the more traditional small chemical compounds. However, the binding …
an alternative to the more traditional small chemical compounds. However, the binding …