Neural circuits for the adaptive regulation of fear and extinction memory

SL Plas, T Tuna, H Bayer, VAL Juliano… - Frontiers in Behavioral …, 2024 - frontiersin.org
The regulation of fear memories is critical for adaptive behaviors and dysregulation of these
processes is implicated in trauma-and stress-related disorders. Treatments for these …

[HTML][HTML] In relentless pursuit of the white whale: a role for the ventral midline thalamus in behavioral flexibility and adaption?

E Panzer, I Guimares-Olmo, AP de Vasconcelos… - Neuroscience & …, 2024 - Elsevier
The reuniens (Re) nucleus is located in the ventral midline thalamus. It has fostered
increasing interest, not only for its participation in a variety of cognitive functions (eg, spatial …

Periplaneta Americana (L.) extract activates the ERK/CREB/BDNF pathway to promote post-stroke neuroregeneration and recovery of neurological functions in rats

J Rao, H Li, H Zhang, X **ang, X Ding, L Li… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Periplaneta americana (L.)(PA) has been used in
traditional Chinese medicine for thousands of years for the effect of invigorating blood …

Chemogenetic inactivation of the nucleus reuniens and its projections to the orbital cortex produce deficits on discrete measures of behavioral flexibility in the …

AKP Rojas, SB Linley, RP Vertes - Behavioural Brain Research, 2024 - Elsevier
The nucleus reuniens (RE) of the ventral midline thalamus is a critical node in the
communication between the orbitomedial prefrontal cortex (OFC) and the hippocampus …

An ultra-short-acting benzodiazepine in thalamic nucleus reuniens undermines fear extinction via intermediation of hippocamposeptal circuits

H Cheung, TZ Yu, X Yi, YJ Wu, Q Wang, X Gu… - Communications …, 2024 - nature.com
Benzodiazepines, commonly used for anxiolytics, hinder conditioned fear extinction, and the
underlying circuit mechanisms are unclear. Utilizing remimazolam, an ultra-short-acting …

Diencephalic modulation of the hippocampus in affective and cognitive behavior

RP Vertes, SB Linley, AKP Rojas, K Lamothe… - Current Opinion in …, 2024 - Elsevier
Highlights•The two major diencephalic inputs to the hippocampus are the nucleus reuniens
and the supramammillary nucleus.•The nucleus reuniens serves a critical role in spatial …

[HTML][HTML] Cognitive dysfunction in early experimental metabolic dysfunction-associated steatotic liver disease is associated with systemic inflammation and …

K Kjærgaard, ACD Mikkelsen, AM Landau, PL Eriksen… - JHEP Reports, 2024 - Elsevier
Background & Aims Cognitive dysfunction is an increasingly recognised manifestation of
metabolic dysfunction-associated steatotic liver disease (MASLD), but the mechanistic link …

Virtual reality modulating dynamics of neuroplasticity: Innovations in neuro-motor rehabilitation

NL Wankhede, S Koppula, S Ballal, H Doshi… - Neuroscience, 2025 - Elsevier
Virtual reality (VR) technology has emerged as a ground-breaking tool in neuroscience,
revolutionizing our understanding of neuroplasticity and its implications for neurological …

CA1 engram cell dynamics before and after learning

A Monasterio, C Lienkaemper, S Coello, GK Ocker… - bioRxiv, 2024 - biorxiv.org
A fundamental question in neuroscience is how memory formation shapes brain activity at
the level of populations of neurons. Recent studies of hippocampal 'engram'cells, identified …

Domain-selective and sex-dependent regulation of learning and memory in mice by GIRK channel activity in CA1 pyramidal neurons of the dorsal hippocampus

H Luo, MK Frederick, EMF de Velasco… - Learning & …, 2024 - learnmem.cshlp.org
G protein-gated inwardly rectifying K+ (GIRK) channels mediate the postsynaptic inhibitory
effect of many neurotransmitters in the hippocampus and are implicated in neurological …