It took more than 100 years before it was established that the proteins that form intermediate
filaments (IFs) comprise a unified protein family, the members of which are ubiquitous in …

Intermediate filaments are cytoskeletal polymers encoded by a large family of differentially
expressed genes that provide crucial structural support in the cytoplasm and nucleus of …

Activation of the NLRP3 inflammasome and subsequent maturation of IL-1β have been
implicated in acute lung injury (ALI), resulting in inflammation and fibrosis. We investigated …

Objective Modification of antigens represents a trigger for the generation of autoantibodies.
In the pathogenesis of rheumatoid arthritis (RA), citrullination of proteins has been shown to …

Background—Sildenafil, a phosphodiesterase-5 inhibitor, induces cardioprotection against
ischemia/reperfusion injury via opening of mitochondrial KATP channels. It is unclear …

Chronic kidney disease (CKD) is characterized by pathological accumulation of extracellular
matrix (ECM) proteins in renal structures. Tubulointerstitial fibrosis is observed in glomerular …

Monoclonal antibodies that specifically recognize caspase cleaved K18 fragments or
specific (phospho) epitopes on intact K8 and K18 were used for a detailed investigation of …

Apoptosis is a genetically programmed and physiological mode of cell death that leads to
the removal of unwanted or abnormal cells. Cysteine-proteases called caspases are …

Keratins that are overexpressed selectively in human carcinomas may offer diagnostic and
prognostic utility. In this study, we show that high expression of keratin-17 (K17) predicts …

Intermediate filaments (IF) form the structural framework of the cytoskeleton. Although
histopathological detection of IF proteins is utilized for examining cancer specimens as …