Structural analysis of resistance-nodulation cell division transporters
PA Klenotic, EW Yu - Microbiology and Molecular Biology Reviews, 2024 - journals.asm.org
Infectious bacteria have both intrinsic and acquired mechanisms to combat harmful biocides
that enter the cell. Through adaptive pressures, many of these pathogens have become …
that enter the cell. Through adaptive pressures, many of these pathogens have become …
Drug resistance and physiological roles of RND multidrug efflux pumps in Salmonella enterica, Escherichia coli and Pseudomonas aeruginosa
Drug efflux pumps transport antimicrobial agents out of bacteria, thereby reducing the
intracellular antimicrobial concentration, which is associated with intrinsic and acquired …
intracellular antimicrobial concentration, which is associated with intrinsic and acquired …
Cryo-EM structures of the Klebsiella pneumoniae AcrB multidrug efflux pump
The continued challenges of the COVID-19 pandemic combined with the growing problem of
antimicrobial-resistant bacterial infections has severely impacted global health. Specifically …
antimicrobial-resistant bacterial infections has severely impacted global health. Specifically …
Molecular insights into the determinants of substrate specificity and efflux inhibition of the RND efflux pumps AcrB and AdeB
Gram-negative bacterial members of the Resistance Nodulation and cell Division (RND)
superfamily form tripartite efflux pump systems that span the cell envelope. One of the …
superfamily form tripartite efflux pump systems that span the cell envelope. One of the …
Cryo-EM structures of CusA reveal a mechanism of metal-ion export
Gram-negative bacteria utilize the resistance-nodulation-cell division (RND) superfamily of
efflux pumps to expel a variety of toxic compounds from the cell. The Escherichia coli CusA …
efflux pumps to expel a variety of toxic compounds from the cell. The Escherichia coli CusA …
[HTML][HTML] Recent Advances in Antimicrobial Resistance: Insights from Escherichia coli as a Model Organism
Z Zhang, M Wei, B Jia, Y Yuan - Microorganisms, 2024 - mdpi.com
Antimicrobial resistance (AMR) represents a critical global health threat, and a thorough
understanding of resistance mechanisms in Escherichia coli is needed to guide effective …
understanding of resistance mechanisms in Escherichia coli is needed to guide effective …
Insights into substrate recognition and export tunnel preferences in the efflux transporter AcrB
F Makhamadjamonov, ME Karolak, L Smyth… - Protein …, 2025 - Wiley Online Library
Abstract In Escherichia coli AcrB is a major multidrug exporter, which confers the bacterium
resistance to many antibiotics with diverse structural and chemical proprieties. Studies have …
resistance to many antibiotics with diverse structural and chemical proprieties. Studies have …
The mycobacterium lipid transporter MmpL3 is dimeric in detergent solution, SMALPs and reconstituted nanodiscs
The mycobacterial membrane protein large 3 (MmpL3) transports key precursor lipids to the
outer membrane of Mycobacterium species. Multiple structures of MmpL3 from both M …
outer membrane of Mycobacterium species. Multiple structures of MmpL3 from both M …
Electrochemical Detection of Tobramycin Resistance in Escherichia Coli
The development of techniques to detect the presence of resistance in pathogens are
urgently needed to face the deadly spread of multi-drug-resistant bacteria. The present work …
urgently needed to face the deadly spread of multi-drug-resistant bacteria. The present work …
[HTML][HTML] Bacteriophage LHE83 targeting OmpA as a receptor exhibited synergism with spectinomycin against Escherichia coli
J Zhen, R Liu, C Man, S Xu, W Zhang, L Zou, W Liu… - Poultry Science, 2024 - Elsevier
Understanding the characteristics of bacteriophages is crucial for the optimization of phage
therapy. In this study, the biological and genomic characteristics of coliphage LHE83 were …
therapy. In this study, the biological and genomic characteristics of coliphage LHE83 were …