Immune targets for therapeutic development in depression: towards precision medicine

WC Drevets, GM Wittenberg, ET Bullmore… - Nature reviews Drug …, 2022‏ - nature.com
Over the past two decades, compelling evidence has emerged indicating that immune
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …

Developmental trajectories of early life stress and trauma: a narrative review on neurobiological aspects beyond stress system dysregulation

A Agorastos, P Pervanidou, GP Chrousos… - Frontiers in …, 2019‏ - frontiersin.org
Early life stressors display a high universal prevalence and constitute a major public health
problem. Prolonged psychoneurobiological alterations as sequelae of early life stress (ELS) …

DNA methylation signatures in peripheral blood strongly predict all-cause mortality

Y Zhang, R Wilson, J Heiss, LP Breitling… - Nature …, 2017‏ - nature.com
DNA methylation (DNAm) has been revealed to play a role in various diseases. Here we
performed epigenome-wide screening and validation to identify mortality-related DNAm …

[HTML][HTML] Epigenetics of stress-related psychiatric disorders and gene× environment interactions

T Klengel, EB Binder - Neuron, 2015‏ - cell.com
A deeper understanding of the pathomechanisms leading to stress-related psychiatric
disorders is important for the development of more efficient preventive and therapeutic …

[HTML][HTML] Glucocorticoid receptor gene (NR3C1) methylation processes as mediators of early adversity in stress-related disorders causality: a critical review

H Palma-Gudiel, A Córdova-Palomera, JC Leza… - Neuroscience & …, 2015‏ - Elsevier
Early life stress (ELS) is a known risk factor for suffering psychopathology in adulthood. The
hypothalamic–pituitary–adrenal (HPA) axis has been described to be deregulated in both …

The molecular and cellular mechanisms of depression: a focus on reward circuitry

ME Fox, MK Lobo - Molecular psychiatry, 2019‏ - nature.com
Depression is a complex disorder that takes an enormous toll on individual health. As
affected individuals display a wide variation in their clinical symptoms, the precise neural …

[ספר][B] The psychology of religion: An empirical approach

RW Hood Jr, PC Hill, B Spilka - 2009‏ - books.google.com
Scholarly and comprehensive yet accessible, this state-of-the-science work is widely
regarded as the definitive graduate-level psychology of religion text. The authors synthesize …

Intergenerational transmission of maternal childhood maltreatment exposure: implications for fetal brain development

C Buss, S Entringer, NK Moog, P Toepfer… - Journal of the American …, 2017‏ - Elsevier
Objective Growing evidence suggests the deleterious consequences of exposure to
childhood maltreatment (CM) not only might endure over the exposed individual's lifespan …

Stress, burnout and depression: A systematic review on DNA methylation mechanisms

J Bakusic, W Schaufeli, S Claes, L Godderis - Journal of psychosomatic …, 2017‏ - Elsevier
Despite that burnout presents a serious burden for modern society, there are no diagnostic
criteria. Additional difficulty is the differential diagnosis with depression. Consequently, there …

BECon: a tool for interpreting DNA methylation findings from blood in the context of brain

RD Edgar, MJ Jones, MJ Meaney, G Turecki… - Translational …, 2017‏ - nature.com
Tissue differences are one of the largest contributors to variability in the human DNA
methylome. Despite the tissue-specific nature of DNA methylation, the inaccessibility of …