Fungal infections are a global concern and the evolution of intrinsic resistance to current
antifungals presents an alarming problem. For Cryptococcus neoformans, a human fungal …

The global burden of fungal disease poses a substantial threat to human, animal, and
environmental health, endangering both human and livestock populations and creating …

This chapter discusses the Infections of the central nervous system (CNS) are among the
most devastating infectious diseases worldwide and often result in medical emergencies …

Central nervous system (CNS) cryptococcosis in non-HIV infected patients affects solid
organ transplant (SOT) recipients, patients with malignancy, rheumatic disorders, other …

Microbial communities of the human microbiota exhibit diverse effects on human health and
disease. Microbial homeostasis is important for normal physiological functions and changes …

Nutrient sensing is critical for adaptation of fungi to environmental and host conditions. The
conserved cAMP/PKA signaling pathway contributes to adaptation by sensing the …

Fungal pathogens cause over 6.5 million life-threatening systemic infections annually, with
mortality rates ranging from 20 to 95%, even with medical intervention. The World Health …

Up to 1.5 million people die yearly from fungal disease, but the repertoire of antifungal drug
classes is minimal and the incidence of drug resistance is rising rapidly. This dilemma was …

Cryptococcal meningitis is the most common cause of meningitis among HIV/AIDS patients
in sub-Saharan Africa, and worldwide causes over 223,000 cases leading to more than …

Background. Cryptococcosis is one of the most common fungal infections in
immunocompromised patients, which is caused by Cryptococcus neoformans. However …