Reconciling qualitative, abstract, and scalable modeling of biological networks

L Paulevé, J Kolčák, T Chatain, S Haar - Nature communications, 2020 - nature.com
Predicting biological systems' behaviors requires taking into account many molecular and
genetic elements for which limited information is available past a global knowledge of their …

Causal analysis of positive reaction systems

L Brodo, R Bruni, M Falaschi, R Gori, P Milazzo… - International Journal on …, 2024 - Springer
Cause/effect analysis of complex systems is instrumental in better understanding many
natural phenomena. Moreover, formal analysis requires the availability of suitable abstract …

Complexity of the dynamics of reaction systems

A Dennunzio, E Formenti, L Manzoni… - Information and …, 2019 - Elsevier
Reaction systems are discrete dynamical systems inspired by bio-chemical processes,
whose dynamical behaviour is expressed by set-theoretic operations on finite sets. Reaction …

Pure reaction automata

R Ascone, G Bernardini, E Formenti, F Leiter… - Natural Computing, 2024 - Springer
This work introduces the new class of pure reaction automata, as well as a new update
manner, called maximal reactive manner, that can also be applied to standard reaction …

Fixed points and attractors of additive reaction systems

R Ascone, G Bernardini, L Manzoni - Natural Computing, 2024 - Springer
Reaction systems are discrete dynamical systems that simulate biological processes within
living cells through finite sets of reactants, inhibitors, and products. In this paper, we study …

Model checking temporal properties of reaction systems

A Męski, W Penczek, G Rozenberg - Information Sciences, 2015 - Elsevier
This paper defines a temporal logic for reaction systems (rsCTL). The logic is interpreted
over the models for the context restricted reaction systems that generalise standard reaction …

[HTML][HTML] Evolving reaction systems

A Ehrenfeucht, J Kleijn, M Koutny… - Theoretical Computer …, 2017 - Elsevier
Reaction systems were introduced as a formal model of interactions between biochemical
reactions. These interactions, which are based on two mechanisms: facilitation and …

Boolean networks and their dynamics: the impact of updates

L Paulevé, S Sené - Systems biology modelling and analysis …, 2022 - Wiley Online Library
Boolean networks are a mathematical model that has been widely used since decades in
the context of biological regulation networks' qualitative modelling. They consist in …

Reaction systems: a model of computation inspired by the functioning of the living cell

A Ehrenfeucht, I Petre, G Rozenberg - The role of theory in …, 2017 - World Scientific
Reaction systems are a model of computation inspired by the functioning of the living cell.
They formalize the interactions between biochemical reactions that form the basic …

[HTML][HTML] Complexity of model checking for reaction systems

S Azimi, C Gratie, S Ivanov, L Manzoni, I Petre… - Theoretical Computer …, 2016 - Elsevier
Reaction systems are a new mathematical formalism inspired by the living cell and driven by
only two basic mechanisms: facilitation and inhibition. As a modeling framework, they differ …