Biological functions of tear film

SC Pflugfelder, ME Stern - Experimental eye research, 2020 - Elsevier
Tears have a vital function to protect and lubricate the ocular surface. Tear production,
distribution and clearance is tightly regulated by the lacrimal functional unit (LFU) to meet …

The pathophysiology of dry eye disease: what we know and future directions for research

SC Pflugfelder, CS de Paiva - Ophthalmology, 2017 - Elsevier
Clinical and laboratory studies performed over the past few decades have discovered that
dry eye is a chronic inflammatory disease that can be initiated by numerous extrinsic or …

The international workshop on meibomian gland dysfunction: report of the subcommittee on management and treatment of meibomian gland dysfunction

G Geerling, J Tauber, C Baudouin… - … & visual science, 2011 - iovs.arvojournals.org
The goals of the subcommittee were to review the current practice and published evidence
of medical and surgical treatment options for meibomian gland dysfunction (MGD) and to …

Biochemistry of human tear film: A review

S Masoudi - Experimental eye research, 2022 - Elsevier
The precorneal tear film is a complex mixture of proteins, lipids, metabolites, and electrolytes
with different structures and functionalities. Sustainable production of each tear component …

Dry eye as a mucosal autoimmune disease

ME Stern, CS Schaumburg… - International reviews of …, 2013 - Taylor & Francis
Dry eye is a common ocular surface inflammatory disease that significantly affects quality of
life. Dysfunction of the lacrimal function unit (LFU) alters tear composition and breaks ocular …

[HTML][HTML] Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface

L Luo, DQ Li, A Doshi, W Farley… - … & visual science, 2004 - tvst.arvojournals.org
purpose. To evaluate whether experimentally induced dry eye in mice activates mitogen-
activated protein kinase (MAPK) signaling pathways, c-Jun N-terminal kinases (JNK) …

Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye

CS De Paiva, RM Corrales, AL Villarreal… - Experimental eye …, 2006 - Elsevier
We investigated the effects of corticosteroid and doxycycline on expression of matrix
metalloproteinase (MMP)-9 and inflammatory cytokines and activation of mitogen-activated …

[HTML][HTML] Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome

S Chotikavanich, CS de Paiva, JJ Chen… - … & visual science, 2009 - arvojournals.org
purpose. To evaluate production and activity of metalloproteinase (MMP)-9 on the ocular
surface of patients with dysfunctional tear syndrome (DTS) and determine any correlation …

[HTML][HTML] Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells

DQ Li, Z Chen, XJ Song, L Luo… - … ophthalmology & visual …, 2004 - arvojournals.org
purpose. To investigate whether exposure of human corneal epithelial cells to hyperosmotic
stress activates the c-Jun NH 2-terminal kinase (JNK) stress-activated protein kinase (SAPK) …

[HTML][HTML] Elevated expression of matrix metalloproteinase-9 and inflammatory cytokines in keratoconus patients is inhibited by cyclosporine A

R Shetty, A Ghosh, RR Lim… - … & visual science, 2015 - tvst.arvojournals.org
Purpose.: The present study was designed to understand the role of inflammatory cytokines
secreted by corneal epithelial cells in keratoconus (KC) and the response to treatment with …