Brain connectomics: time for a molecular imaging perspective?

A Sala, A Lizarraga, SP Caminiti, VD Calhoun… - Trends in cognitive …, 2023 - cell.com
In the past two decades brain connectomics has evolved into a major concept in
neuroscience. However, the current perspective on brain connectivity and how it underpins …

The metabolic costs of cognition

SD Jamadar, A Behler, H Deery… - Trends in Cognitive …, 2024 - cell.com
Cognition and behavior are emergent properties of brain systems that seek to maximize
complex and adaptive behaviors while minimizing energy utilization. Different species …

Functional PET/MRI reveals active inhibition of neuronal activity during optogenetic activation of the nigrostriatal pathway

S Haas, F Bravo, TM Ionescu… - Science …, 2024 - science.org
The dopaminergic system is a central component of the brain's neurobiological framework,
governing motor control and reward responses and playing an essential role in various …

Task-evoked metabolic demands of the posteromedial default mode network are shaped by dorsal attention and frontoparietal control networks

GM Godbersen, S Klug, W Wadsak, V Pichler… - Elife, 2023 - elifesciences.org
External tasks evoke characteristic fMRI BOLD signal deactivations in the default mode
network (DMN). However, for the corresponding metabolic glucose demands both …

Dissociations between glucose metabolism and blood oxygenation in the human default mode network revealed by simultaneous PET-fMRI

LJ Stiernman, F Grill, A Hahn, L Rischka… - Proceedings of the …, 2021 - pnas.org
The finding of reduced functional MRI (fMRI) activity in the default mode network (DMN)
during externally focused cognitive control has been highly influential to our understanding …

1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain

P Bednarik, D Goranovic, A Svatkova, F Niess… - Nature Biomedical …, 2023 - nature.com
Impaired glucose metabolism in the brain has been linked to several neurological disorders.
Positron emission tomography and carbon-13 magnetic resonance spectroscopic imaging …

High-temporal resolution functional PET/MRI reveals coupling between human metabolic and hemodynamic brain response

A Hahn, MB Reed, C Vraka, GM Godbersen… - European Journal of …, 2024 - Springer
Purpose Positron emission tomography (PET) provides precise molecular information on
physiological processes, but its low temporal resolution is a major obstacle. Consequently …

[HTML][HTML] Whole-body metabolic connectivity framework with functional PET

MB Reed, MP de León, C Vraka, I Rausch… - Neuroimage, 2023 - Elsevier
The nervous and circulatory system interconnects the various organs of the human body,
building hierarchically organized subsystems, enabling fine-tuned, metabolically expensive …

Reconfiguration of functional brain networks and metabolic cost converge during task performance

A Hahn, M Breakspear, L Rischka, W Wadsak… - elife, 2020 - elifesciences.org
The ability to solve cognitive tasks depends upon adaptive changes in the organization of
whole-brain functional networks. However, the link between task-induced network …

Dynamics of human serotonin synthesis differentially link to reward anticipation and feedback

A Hahn, MB Reed, M Murgaš, C Vraka, S Klug… - Molecular …, 2024 - nature.com
Abstract Serotonin (5-HT) plays an essential role in reward processing, however, the
possibilities to investigate 5-HT action in humans during emotional stimulation are …