Diagnosis and management of bipolar disorders

FS Goes - bmj, 2023 - bmj.com
Bipolar disorders (BDs) are recurrent and sometimes chronic disorders of mood that affect
around 2% of the world's population and encompass a spectrum between severe elevated …

Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11. 2 deletion syndrome: a review of ENIGMA …

EJ Cheon, CE Bearden, D Sun… - Psychiatry and …, 2022 - Wiley Online Library
This review compares the main brain abnormalities in schizophrenia (SZ), bipolar disorder
(BD), major depressive disorder (MDD), and 22q11. 2 Deletion Syndrome (22q11DS) …

Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression

S Larivière, J Royer, R Rodríguez-Cruces… - Nature …, 2022 - nature.com
Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations,
but associations between neurobiological mechanisms and macroscale connectomics …

[HTML][HTML] Longitudinal structural brain changes in bipolar disorder: a multicenter neuroimaging study of 1232 individuals by the ENIGMA bipolar disorder working group

C Abé, CRK Ching, B Liberg, AV Lebedev, I Agartz… - Biological …, 2022 - Elsevier
Background Bipolar disorder (BD) is associated with cortical and subcortical structural brain
abnormalities. It is unclear whether such alterations progressively change over time, and …

Prefrontal, parietal, and limbic condition-dependent differences in bipolar disorder: a large-scale meta-analysis of functional neuroimaging studies

MC Schumer, HW Chase, R Rozovsky… - Molecular …, 2023 - nature.com
Background Over the past few decades, neuroimaging research in Bipolar Disorder (BD)
has identified neural differences underlying cognitive and emotional processing. However …

Genomics yields biological and phenotypic insights into bipolar disorder

KS O'Connell, M Koromina, T van der Veen, T Boltz… - Nature, 2025 - nature.com
Bipolar disorder is a leading contributor to the global burden of disease. Despite high
heritability (60–80%), the majority of the underlying genetic determinants remain unknown …

Segregation, integration and balance in resting‐state brain functional networks associated with bipolar disorder symptoms

Z Chang, X Wang, Y Wu, P Lin… - Human Brain Map**, 2023 - Wiley Online Library
Bipolar disorder (BD) is a serious mental disorder involving widespread abnormal
interactions between brain regions, and it is believed to be associated with imbalanced …

The enhancing NeuroImaging genetics through meta‐analysis consortium: 10 Years of global collaborations in human brain map**

PM Thompson, N Jahanshad, L Schmaal… - Human brain …, 2022 - Wiley Online Library
Abstract This Special Issue of Human Brain Map** is dedicated to a 10‐year anniversary
of the Enhancing NeuroImaging Genetics through Meta‐Analysis (ENIGMA) Consortium. It …

The impact of childhood trauma on develo** bipolar disorder: current understanding and ensuring continued progress

Y Quidé, L Tozzi, M Corcoran, DM Cannon… - Neuropsychiatric …, 2020 - Taylor & Francis
Childhood trauma (CT) has been repeatedly linked to earlier onset and greater severity of
bipolar disorder (BD) in adulthood. However, such knowledge is mostly based on …

Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids

JR Osete, IA Akkouh, O Ievglevskyi… - Molecular …, 2023 - nature.com
Lithium (Li) is recommended for long-term treatment of bipolar disorder (BD). However, its
mechanism of action is still poorly understood. Induced pluripotent stem cell (iPSC)-derived …