Recent developments on the potential biological applications of transition metal complexes of thiosemicarbazone derivatives

V Singh, VNV Palakkeezhillam, V Manakkadan… - Polyhedron, 2023 - Elsevier
This review talks about the synthesis, and coordination chemistry of thiosemicarbazone and
its bonding with transition metals like copper, nickel, zinc, palladium, and ruthenium and …

Synthesis of palladium (II) complexes via Michael addition: antiproliferative effects through ROS-mediated mitochondrial apoptosis and docking with SARS-CoV-2

J Haribabu, S Srividya, D Mahendiran… - Inorganic …, 2020 - ACS Publications
Metal complexes have numerous applications in the current era, particularly in the field of
pharmaceutical chemistry and catalysis. A novel synthetic approach for the same is always a …

Isatin: A scaffold with immense biodiversity

P Nath, A Mukherjee, S Mukherjee… - Mini Reviews in …, 2021 - ingentaconnect.com
Isatin is an endogenous and a significant category of fused heterocyclic components and
has widely been a part of several potential biologically useful synthetics. Since its discovery …

Effect of N-benzyl group in indole scaffold of thiosemicarbazones on the biological activity of their Pd (II) complexes: DFT, biomolecular interactions, in silico docking …

N Balakrishnan, J Haribabu, RE Malekshah… - Inorganica Chimica …, 2022 - Elsevier
A series of N-benzyl substituted indole-based thiosemicarbazone (TSC) ligands (L4-L6) and
palladium (II) TSC complexes,[Pd (L) 2](1–6)(L= monoanionic bidentate un/N-substituted …

Nickel (II) bis (isatin thiosemicarbazone) complexes induced apoptosis through mitochondrial signaling pathway and G0/G1 cell cycle arrest in IM-9 cells

C Balachandran, J Haribabu, K Jeyalakshmi… - Journal of Inorganic …, 2018 - Elsevier
Abstract Three novel complexes (1, 3 and 4) ligating N-substituted isatin thiosemicarbazone
derivatives have been synthesized and their structural and biological characteristics have …

Exploring the anticancer potential of thiadiazole derivatives of substituted thiosemicarbazones formed via copper‐mediated cyclization

VN Vadakkedathu Palakkeezhillam… - Applied …, 2023 - Wiley Online Library
A couple of N‐(4)‐morpholine/pyrrolidine‐substituted thiosemicarbazones (TSCs) of
fluorene‐2‐carboxaldehyde (FM and FP), and their corresponding thiadiazoles (TDZs)(CFM …

Synthesis, structures and mechanistic pathways of anticancer activity of palladium (II) complexes with indole-3-carbaldehyde thiosemicarbazones

J Haribabu, MM Tamizh, C Balachandran… - New Journal of …, 2018 - pubs.rsc.org
New PdII complexes of the types [PdCl (L)(PPh3)](1–5) and [Pd (L) 2](6 and 7)(HL= indole-3-
carbaldehyde thiosemicarbazones, HL1–HL5) have been synthesized in order to ascertain …

Investigation on bovine serum albumin (BSA) binding efficiency and antibacterial activity of ZnO nanoparticles

AR Prasad, SM Basheer, IR Gupta, KK Elyas… - Materials Chemistry and …, 2020 - Elsevier
Biomolecule-NPs interaction is extremely important in various biomedical applications
especially for assessing the macrostructural effects of nanoparticles on proteins. We …

Cu (II) and Ni (II) complexes with new tridentate NNS thiosemicarbazones: synthesis, characterisation, DNA interaction, and antibacterial activity

D Polo-Cerón - Bioinorganic chemistry and applications, 2019 - Wiley Online Library
This paper reports the synthesis and detailed characterisation of copper (II) and nickel (II)
complexes with tridentate thiosemicarbazone ligands H2L1 and H2L2 derived from 2 …

DNA and BSA binding studies of new Pd (II) bisthiocarbohydrazone complexes: from anticancer drug analogue to anticovid candidates

KKM Hashim, E Manoj - Inorganic Chemistry Communications, 2023 - Elsevier
Two new Pd (II) complexes derived from bioactive 1, 5-bis (2-benzoylpyridine)
thiocarbohydrazone (1) and 1, 5-bis (di (2-pyridyl) ketone) thiocarbohydrazone (2) are found …