Alzheimer's disease (AD) is the most common form of dementia worldwide. β-amyloid
peptide (Aβ) is currently assumed to be the main cause of synaptic dysfunction and cognitive …

Convincing evidence has repeatedly shown that new neurons are produced in the
mammalian brain into adulthood. Adult neurogenesis has been best described in the …

Abstract Changes in the levels and activities of neurotrophic factors, such as brain-derived
neurotrophic factor (BDNF), have been described in a number of neurodegenerative …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

Protein kinases are a growing drug target class in disorders in peripheral tissues, but the
development of kinase-targeted therapies for central nervous system (CNS) diseases …

Huntington's disease (HD) is a fatal degenerative autosomal dominant neuropsychiatric
disease that causes neuronal death and is characterized by progressive striatal and then …

Huntington's disease (HD) is a genetically dominant condition caused by expanded CAG
repeats. These repeats code for a glutamine tract in the HD gene product huntingtin (htt) …

Reduced Brain-Derived Neurotrophic Factor (BDNF) levels have been described in a
number of patho-physiological conditions, most notably, in Huntington's disease (HD), a …

Caused by a polyglutamine expansion in the huntingtin protein, Huntington's disease leads
to striatal degeneration via the transcriptional dysregulation of a number of genes, including …

Huntington's disease (HD) is a devastating neurodegenerative disorder with no disease-
modifying treatments available. The disease is caused by expansion of a CAG trinucleotide …