Designing the next-generation clinical care pathway for Alzheimer's disease

H Hampel, R Au, S Mattke, WM van der Flier, P Aisen… - Nature Aging, 2022 - nature.com
The reconceptualization of Alzheimer's disease (AD) as a clinical and biological construct
has facilitated the development of biomarker-guided, pathway-based targeted therapies …

[HTML][HTML] Precision and personalized medicine: how genomic approach improves the management of cardiovascular and neurodegenerative disease

O Strianese, F Rizzo, M Ciccarelli, G Galasso… - Genes, 2020 - mdpi.com
Life expectancy has gradually grown over the last century. This has deeply affected
healthcare costs, since the growth of an aging population is correlated to the increasing …

DementiaBank: Theoretical rationale, protocol, and illustrative analyses

AM Lanzi, AK Saylor, D Fromm, H Liu… - American Journal of …, 2023 - pubs.asha.org
Purpose: Dementia from Alzheimer's disease (AD) is characterized primarily by a significant
decline in memory abilities; however, language abilities are also commonly affected and …

Precision public health in the era of genomics and big data

MC Roberts, KE Holt, G Del Fiol, AA Baccarelli… - Nature Medicine, 2024 - nature.com
Precision public health (PPH) considers the interplay between genetics, lifestyle and the
environment to improve disease prevention, diagnosis and treatment on a population level …

Why loneliness interventions are unsuccessful: A call for precision health

SC Akhter-Khan, R Au - Advances in geriatric medicine and …, 2020 - pmc.ncbi.nlm.nih.gov
Background: Loneliness has drawn increasing attention over the past few decades due to
rising recognition of its close connection with serious health issues, like dementia. Yet …

A systems approach towards remote health-monitoring in older adults: Introducing a zero-interaction digital exhaust

N Schütz, SEJ Knobel, A Botros, M Single, B Pais… - NPJ digital …, 2022 - nature.com
Using connected sensing devices to remotely monitor health is a promising way to help
transition healthcare from a rather reactive to a more precision medicine oriented proactive …

Components, prospects and challenges of personalized prevention

S Jaskulski, C Nuszbaum, KB Michels - Frontiers in Public Health, 2023 - frontiersin.org
Effective preventive strategies are urgently needed to address the rising burden of non-
communicable diseases such as cardiovascular disease and cancer. To date, most …

[HTML][HTML] Cerebral Microbleeds in Different Brain Regions and Their Associations With the Digital Clock-Drawing Test: Secondary Analysis of the Framingham Heart …

SC Akhter-Khan, Q Tao, TFA Ang, C Karjadi… - Journal of Medical …, 2024 - jmir.org
Background Cerebral microbleeds (CMB) increase the risk for Alzheimer disease. Current
neuroimaging methods that are used to detect CMB are costly and not always accessible …

A novel online training programme for healthcare professionals caring for older adults

JP Michel, F Ecarnot, H Arai, LK Chen - Aging clinical and experimental …, 2023 - Springer
The proportion of older people in the world population is growing rapidly. Training and
retaining healthcare professionals in sufficient numbers in the field of ageing represents a …

[HTML][HTML] Digital clock drawing as an Alzheimer's disease susceptibility biomarker: associations with genetic risk score and APOE in older adults

LI Thompson, M Cummings, S Emrani, DJ Libon… - The journal of …, 2024 - Elsevier
Background Alzheimer's disease (AD) is the leading cause of dementia in older adults, but
most people are not diagnosed until significant neuronal loss has likely occurred along with …