Infection with Mycobacterium tuberculosis causes> 1.5 million deaths worldwide annually.
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …

Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

Mycobacterium tuberculosis (Mtb) infection is initiated in the distal airways, but the bacteria
ultimately disseminate to the lung interstitium. Although various cell types, including alveolar …

Summary β-glucan is a potent inducer of epigenetic and functional reprogramming of innate
immune cells, a process called" trained immunity," resulting in an enhanced host response …

Chemokines and cytokines are critical for initiating and coordinating the organized and
sequential recruitment and activation of cells into Mycobacterium tuberculosis-infected …

Toll-like receptors (TLRs) are germline-encoded pattern recognition receptors (PRRs) that
play a central role in host cell recognition and responses to microbial pathogens. TLR …

There are 9 million cases of active tuberculosis reported annually; however, an estimated
one-third of the world's population is infected with Mycobacterium tuberculosis and remains …

The granuloma, which is a compact aggregate of immune cells, is the hallmark structure of
tuberculosis. It is historically regarded as a host-protective structure that'walls off'the infecting …

Cytosolic detection of microbial products is essential for the initiation of an innate immune
response against intracellular pathogens such as Mycobacterium tuberculosis (Mtb). During …

Nitric oxide contributes to protection from tuberculosis. It is generally assumed that this
protection is due to direct inhibition of Mycobacterium tuberculosis growth, which prevents …