Lipid polymer hybrid nanoparticles: a custom-tailored next-generation approach for cancer therapeutics

KR Gajbhiye, R Salve, M Narwade, A Sheikh… - Molecular Cancer, 2023 - Springer
Lipid-based polymeric nanoparticles are the highly popular carrier systems for cancer drug
therapy. But presently, detailed investigations have revealed their flaws as drug delivery …

Recent development of aptamer conjugated chitosan nanoparticles as cancer therapeutics

A Sheikh, S Md, NA Alhakamy, P Kesharwani - International Journal of …, 2022 - Elsevier
There is a surge in demand for safe and targeted therapy against cancer as the conventional
treatment approach fails to reach the specific site. Chemotherapeutic agents are generally …

[HTML][HTML] Chitosan-based nanoparticles with optimized parameters for targeted delivery of a specific anticancer drug—a comprehensive review

J Kurczewska - Pharmaceutics, 2023 - mdpi.com
Chitosan is a positively charged polysaccharide obtained through chitin deacetylation. It
belongs to a group of biodegradable, bioavailable, and non-toxic materials of natural origin; …

Folate-engineered chitosan nanoparticles: next-generation anticancer nanocarriers

P Kesharwani, K Halwai, SK Jha, MH Al Mughram… - Molecular Cancer, 2024 - Springer
Chitosan nanoparticles (NPs) are well-recognized as promising vehicles for delivering
anticancer drugs due to their distinctive characteristics. They have the potential to enclose …

Delivery of natural products via polysaccharide-based nanocarriers for cancer therapy: a review on recent advances and future challenges

Y Jiang, C Yan, M Li, S Chen, Z Chen, L Yang… - International Journal of …, 2024 - Elsevier
Cancer, caused by uncontrolled proliferation of abnormal cells, has long been a global
public health issue. For decades, natural products have been proven to be an essential …

Synergistic effects of quercetin-loaded CoFe2O4@Liposomes regulate DNA damage and apoptosis in MCF-7 cancer cells: based on biophysical magnetic …

S Elbeltagi, A Abdel shakor, H M. Alharbi… - Drug Development …, 2024 - Taylor & Francis
Introduction Breast cancer (BC) is the most common malignancy in women globally.
Significant progress has been made in develo** structural nanoparticles (NPs) and …

Folate decorated lipid chitosan hybrid nanoparticles of 5-fluorouracil for enhanced anticancer efficacy against colon cancer

S Khan, A Madni, H Shah, N Jan, A Shafiq… - International Journal of …, 2022 - Elsevier
The study aimed to develop folate decorated lipid chitosan hybrid nanoparticles for targeted
delivery of 5-fluorouracil in colon cancer by utilizing the overexpressed folate receptors on …

[HTML][HTML] Advances in the delivery of anticancer drugs by nanoparticles and chitosan-based nanoparticles

J Prieložná, V Mikušová, P Mikuš - International Journal of Pharmaceutics …, 2024 - Elsevier
Cancer is the leading cause of death globally, and conventional treatments have limited
efficacy with severe side effects. The use of nanotechnology has the potential to reduce the …

Harnessing lipid polymer hybrid nanoparticles for enhanced oral bioavailability of thymoquinone: in vitro and in vivo assessments

SS Imam, SJ Gilani, MN Bin Jumah, M Rizwanullah… - Polymers, 2022 - mdpi.com
The clinical application of phytochemicals such as thymoquinone (THQ) is restricted due to
their limited aqueous solubility and oral bioavailability. Develo** mucoadhesive …

[HTML][HTML] Colonic targeting insulin-loaded trimethyl chitosan nanoparticles coated pectin for oral delivery: In vitro and In vivo studies

S Seyam, H Choukaife, O Al Rahal… - International Journal of …, 2024 - Elsevier
Colon-targeted delivery offers several benefits for oral protein delivery, such as low
proteolytic enzyme activity, a natural pH environment, and extended residence time, which …